3-环己基-5-苯基-1,3-恶唑烷-2-酮合成路线 （共 9 条）
反应条件
sodium hydroxide in diethylene glycol T=130 - 140°C;
参考文献
Wrobel; Bobin; Karczewski
Polish Journal of Chemistry, 2006 , vol. 80, # 6 p. 907 - 912
反应条件
L-histidine base
T=110°C; P=60006 Torr; 36 h; Autoclaveneat (no solvent); regioselective reaction;
参考文献
Jiang, Huan-Feng; Ye, Jin-Wu; Qi, Chao-Rong; Huang, Liang-Bin
Tetrahedron Letters, 2010 , vol. 51, # 6 p. 928 - 932
反应条件
4-(N,N-dimethlyamino)pyridine; [N,N'-bis(3,5-ditBuC6H2CH-2-O-)-1,2-diN-cyclohexan]ClCr(III) in dichloromethane
T=100°C; P=20685.9 Torr; 16 h;
参考文献
Miller, Aaron W.; Nguyen, SonBinh T.
Organic Letters, 2004 , vol. 6, # 14 p. 2301 - 2304
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=20°C; 48 h;
参考文献
Wrobel; Bobin; Karczewski
Polish Journal of Chemistry, 2006 , vol. 80, # 6 p. 907 - 912
反应条件
1: 75 percent / acetonitrile / 0 °C
2: 54 percent / tert-BuOK / dimethylformamide / 48 h / 20 °C
View Scheme
参考文献
Wrobel; Bobin; Karczewski
Polish Journal of Chemistry, 2006 , vol. 80, # 6 p. 907 - 912
反应条件
1: acetonitrile
2: water / 20 °C
3: Br-Ph3+PPEG600P+Ph3Br- / 8 h / 110 °C / 37503.8 Torr / Autoclave; Neat (no solvent)
View Scheme
参考文献
Watile, Rahul A.; Bagal, Dattatraya B.; Patil, Yogesh P.; Bhanage, Bhalchandra M.
Tetrahedron Letters, 2011 , vol. 52, # 48 p. 6383 - 6387
反应条件
1: water / 20 °C
2: Br-Ph3+PPEG600P+Ph3Br- / 8 h / 110 °C / 37503.8 Torr / Autoclave; Neat (no solvent)
View Scheme
参考文献
Watile, Rahul A.; Bagal, Dattatraya B.; Patil, Yogesh P.; Bhanage, Bhalchandra M.
Tetrahedron Letters, 2011 , vol. 52, # 48 p. 6383 - 6387
反应条件
lithium chloride
T=180°C; 10 h;
参考文献
Gulbins,K. et al.
Chemische Berichte, 1960 , vol. 93, p. 1975 - 1982
反应条件
1.1: bromo-dimethylsulfonium bromide / acetonitrile / 0.17 h / Cooling with ice
1.2: 20 °C
2.1: pyridium iodide / 48 h / 25 °C / 22502.3 Torr / Autoclave
View Scheme
参考文献
Yang, Zhen-Zhen; Li, Yu-Nong; Wei, Yang-Yang; He, Liang-Nian
Green Chemistry, 2011 , vol. 13, # 9 p. 2351 - 2353
