(S)-3-羟基丁酸乙酯合成路线 （共 42 条）
反应条件
hydrogen; 4-amino-pyridine; dicobalt octacarbonyl T=40°C; P=7500.75 Torr; 24 h;
参考文献
DAISO CO., LTD.
Patent: EP1616852 A1, 2006 ;
Location in patent: Page/Page column 5 ;
反应条件
[NEt2H2]-[{RuCl(S)-BINAP}2(μ-Cl)3]; hydrogen in methanol; ethanol T=50°C; P=22801.5 Torr; 12 h; Inert atmosphereAutoclave; optical yield given as percent ee;
参考文献
Fernandes, Rodney A.; Mulay, Sandip V.
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 7029 - 7032
反应条件
citrate-phosphate-borate buffer 24 h; Ambient temperaturebaker's yeast immobilized in calcium alginate; Title compound not separated from byproducts;
参考文献
Bhalerao; Chandraprakash; Babu; Fadnavis
Synthetic Communications, 1993 , vol. 23, # 9 p. 1201 - 1208
反应条件
[Ru(η4-COD)(η3-methylallyl)2]; hydrogen in methanol T=60°C; P=30003 Torr; 20 h; Reagent/catalystSolvent; Optical yield = 89 percent ee; enantioselective reaction;
参考文献
Journal of Molecular Catalysis A: Chemical, , vol. 374-375, p. 22 - 26
反应条件
potassium hydroxide in tetrahydrofuran; ethanol
参考文献
Zarbin, Paulo H. G.; De Oliveira, Alfredo R. M.; Delay, Carlos E.
Tetrahedron Letters, 2003 , vol. 44, # 36 p. 6849 - 6851
反应条件
alcohol dehydrogenase from Lactobacillus kefir; alcohol dehydrogenase from Rhodococcus ruber DSM 44541; YcnD-oxidoreductase T=30°C; pH=7.5; 6 h; aq. bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantiospecific reaction;
参考文献
Voss, Constance V.; Gruber, Christian C.; Faber, Kurt; Knaus, Tanja; Macheroux, Peter; Kroutil, Wolfgang
Journal of the American Chemical Society, 2008 , vol. 130, # 42 p. 13969 - 13972
反应条件
erbium trifluoromethanesulfonate T=4°C; 20 h;
参考文献
Vanderwal, Christopher D.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2004 , vol. 126, # 45 p. 14724 - 14725
反应条件
titanium tetraethoxide in ethanol T=130°C; P=3800 Torr; 120 h;
参考文献
Seebach, Dieter; Hungerbuehler, Ernst; Naef, Reto; Schnurrenberger, Peter; Weidmann, Beat; Zueger, Max
Synthesis, 1982 , # 2 p. 138 - 141
反应条件
titanium tetraethoxide in ethanol T=78°C; 96 h;
参考文献
Seebach, Dieter; Hungerbuehler, Ernst; Naef, Reto; Schnurrenberger, Peter; Weidmann, Beat; Zueger, Max
Synthesis, 1982 , # 2 p. 138 - 141
反应条件
lt;(-)-2,2'-bis(diphenylphosphino)-3,3'-bibenzolt;bgt;thiophenegt;RuCl2; hydrogen in methanol T=70°C; P=73550.8 Torr; 2 h; Yield given;
参考文献
Benincori, Tiziana; Brenna, Elisabetta; Sannicolo, Franco; Trimarco, Licia; Antognazza, Patrizia; et al.
Journal of Organic Chemistry, 1996 , vol. 61, # 18 p. 6244 - 6251
