3',5'-二-O-甲磺酰基胸苷合成路线 (共 14 条)
参考文献
Viterbo, Davide; Milanesio, Marco; Pomes Hernandez, Ramon; Rodriguez Tanty, Chryslaine; Colas Gonzalez, Ivan; Sablon Carrazana, Marquiza; Duque Rodriguez, Julio
Acta Crystallographica Section C: Crystal Structure Communications, 2000 , vol. 56, # 5 p. 580 - 581
反应条件
1: aq. NaOH / methanol 2: NaH / dimethylformamide View Scheme
参考文献
Taourirte; Lazrek; Vasseur; Ferrero; Fernandez; Gotor
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 959 - 962
反应条件
1: 85 percent / 1 M KOH / ethanol / 1 h / Heating 2: 1) AlF3, 1percent HF, 2) 1 M NaOH / 1) DMF, 75 min, 100 deg C, 2) EtOH, 20 min, reflux View Scheme
参考文献
Joecks, A.; Koeppel, H.; Schleinitz, K. D.; Cech, D.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 6 p. 881 - 892
反应条件
1: LiBr 2: palladium/BaSO4; aq.-ethanolic NH3 / Hydrogenation 3: palladium/BaSO4; aq.-ethanolic NH3 / Hydrogenation View Scheme
参考文献
Michelson; Todd
Journal of the Chemical Society, 1955 , p. 816,822
反应条件
triethylamine in ethanol 30 h; Reflux;
参考文献
Onambele, Liliane A.; Koth, Daniel; Czaplewska, Justyna A.; Schubert, Ulrich S.; Goerls, Helmar; Yano, Shigenobu; Obata, Makoto; Gottschaldt, Michael; Prokop, Aram
Chemistry - A European Journal, 2010 , vol. 16, # 48 p. 14498 - 14505
反应条件
sodium hydroxide in water Hydrolysis; Heating;
参考文献
Agrofoglio; Girard; Fleury; Leonce
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 599 - 600
反应条件
1.1: NaOH / H2O / Heating 2.1: t-BuOK / dimethylsulfoxide 2.2: toluene 3.1: H2 / Pd/C / 2068.59 Torr View Scheme
参考文献
Agrofoglio; Girard; Fleury; Leonce
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 599 - 600
反应条件
pyridine
T=0°C; 15 h;
参考文献
Lavandera; Fernandez; Ferrero; Gotor
Journal of Organic Chemistry, 2001 , vol. 66, # 11 p. 4079 - 4082
反应条件
pyridine in water; methanesulfonyl chloride
参考文献
Bristol-Myers Company
Patent: US4904770 A1, 1990 ;
反应条件
in 1,4-dioxane
1.5 h; Heating;
参考文献
Huang; Chen; Wang; Kim; Warshaw; Armstrong; Zhu; Chou; Watanabe; Matulic-Adamic; Su; Fox; Polsky; Baron; Gold; Hardy; Zuckerman
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1640 - 1646