3-(三甲基硅基)丙炔酸合成路线 （共 17 条）
反应条件
hydrogen; palladium on activated charcoal 1) 120 deg C, 18 h; 2) methanol; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Hermeling, Dieter; Schaefer, Hans J.
Angewandte Chemie, 1984 , vol. 96, # 3 p. 238 - 239
反应条件
quinoline; hydrogen; Lindlar's catalyst in hexane
Ambient temperature;
参考文献
Hermeling, Dieter; Schaefer, Hans J.
Chemische Berichte, 1988 , vol. 121, p. 1151 - 1158
参考文献
Hermeling, Dieter; Schaefer, Hans J.
Angewandte Chemie, 1984 , vol. 96, # 3 p. 238 - 239
反应条件
quinoline; hydrogen; Lindlar's catalyst in methanol
7 h; Ambient temperature; Yield given;
参考文献
Fleming, Ian; Gil, Salvador; Sarkar, Achintya K.; Schmidlin, Tibur
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 24 p. 3351 - 3362
反应条件
1: H2, quinoline / Pd (10percent on BaSO4) / methanol / 7 h / Ambient temperature
2: oxalyl chloride / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Fleming, Ian; Gil, Salvador; Sarkar, Achintya K.; Schmidlin, Tibur
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 24 p. 3351 - 3362
反应条件
1: 88 percent / H2, quinoline / Lindlar-cat. / hexane / Ambient temperature
2: 12 h / 90 °C
View Scheme
参考文献
Hermeling, Dieter; Schaefer, Hans J.
Angewandte Chemie, 1984 , vol. 96, # 3 p. 238 - 239
反应条件
1: trimethylsilylpropynoyl chloride With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide in dichloromethane
T=20°C; 2.5 h;
2: ethanolamine in tetrahydrofuran
10 h; Further stages.;
参考文献
Hayashi, Ryuji; Jin, Xiaomin; Cook, Gregory R.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6864 - 6870
