2,5-二氨基-4,6-二羟基嘧啶盐酸盐合成路线 （共 10 条）
反应条件
sodium ethanolate 1) EtOH, 30 min, r.t., 2a) EtOH, 18 h, r.t., 2b) 1 h, reflux; Yield given. Multistep reaction;
参考文献
Synthesis, , # 7 p. 587 - 589
反应条件
1: With anhydrous tetramethylammonium chloride; trichlorophosphate in 1,2,3-trichloro propane T=115°C; 24 h; 2: With sodium hydroxide in 1,2,3-trichloro propane; water T=50 - 60°C; pH=6.5 - 7.0; 0.5 h;
参考文献
Lonza AG
Patent: EP1188750 A1, 2002 ;
Location in patent: Page 5 ;
参考文献
Beecham Group p.l.c.
Patent: US5216161 A1, 1993 ;
反应条件
sodium hydroxide; trichlorophosphate in ethyl acetate; acetonitrile
参考文献
Beecham Group p.l.c.
Patent: US5216161 A1, 1993 ;
反应条件
sodium hydroxide; anhydrous tetramethylammonium chloride; trichlorophosphate in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane
参考文献
Lonza AG
Patent: US6271376 B1, 2001 ;
反应条件
sodium hydroxide; trichlorophosphate in N-methyl-acetamide; water
参考文献
DEGISSA AG
Patent: US2007/265287 A1, 2007 ;
反应条件
sodium hydroxide; phosphoric acid; trichlorophosphate in N-methyl-acetamide; water; toluene
参考文献
DEGISSA AG
Patent: US2007/265287 A1, 2007 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=50°C; 0.75 h; 2: 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride T=70 - 90°C; 17.45 - 20.45 h; 3: With sodium hydroxide; water T=20 - 97°C; pH=0.5 - 4.0; 4 - 8 h; Product distribution / selectivity;
参考文献
DEGUSSA AG
Patent: WO2005/68438 A1, 2005 ;
Location in patent: Page/Page column 8-9 ;
反应条件
sodium hydrogencarbonate in ethanol
Heating;
参考文献
Lin; Holmes; Dunn; Skinner
Journal of Medicinal Chemistry, 1979 , vol. 22, # 6 p. 741 - 743
参考文献
Winchester
Journal of Heterocyclic Chemistry, 1979 , vol. 16, # 7 p. 1455 - 1458
