4-氯-6-溴噻吩并[2,3-d]嘧啶合成路线 （共 9 条）
反应条件
trichlorophosphate T=120°C; 3 h;
参考文献
Bugge, Steffen; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bard Helge
Tetrahedron, 2012 , vol. 68, # 45 p. 9226 - 9233
反应条件
1: Br2 2: POCl3 View Scheme
参考文献
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, , vol. 267, p. 697 - 700
反应条件
n-butyllithium; carbon tetrabromide in tetrahydrofuran; hexane T=-78°C; 2.41667 h;
参考文献
US2013/190297 A1, ;
Paragraph 1216; 1217; 1218 ;
反应条件
carbon tetrabromide in tetrahydrofuran T=-78 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 3 p. 844 - 847
反应条件
1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 0 °C / Reflux 2.1: hexane; tetrahydrofuran / 0.42 h / -78 °C 2.2: 2.33 h / -78 - 20 °C View Scheme
反应条件
tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate in 1,4-dioxane T=130°C; Suzuki Coupling; 5 h; ConcentrationSolventTemperatureTime;
参考文献
Tetrahedron, , vol. 68, # 45 p. 9226 - 9233
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in 1,4-dioxane; water T=110°C; Suzuki Coupling; 6 h; ConcentrationSolventTemperatureTime;
参考文献
Tetrahedron, , vol. 68, # 45 p. 9226 - 9233
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran T=-78°C; 1 h; Inert atmosphere;
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; MARUGAN, Juan, J.; ZHENG, Wei; SOUTHALL, Noel; HUANG, Wenwei; MCCOY, Joshua, G.; TITUS, Steven; PATNAIK, Samarjit
Patent: WO2012/44993 A1, 2012 ;
Location in patent: Page/Page column 44 ;
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
2.2: 0.33 h
View Scheme
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; MARUGAN, Juan, J.; ZHENG, Wei; SOUTHALL, Noel; HUANG, Wenwei; MCCOY, Joshua, G.; TITUS, Steven; PATNAIK, Samarjit
Patent: WO2012/44993 A1, 2012 ;
