2,4-二氯-5-甲基噻吩并[2,3-D]嘧啶合成路线 (共 4 条)
反应条件
acetonitrile T=100°C; 15 h; Sealed tube;
参考文献
Roecker, Anthony J.; Mercer, Swati P.; Harrell, C. Meacham; Garson, Susan L.; Fox, Steven V.; Gotter, Anthony L.; Prueksaritanont, Thomayant; Cabalu, Tamara D.; Cui, Donghui; Lemaire, Wei; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 9 p. 2079 - 2085
反应条件
N,N-dimethyl-aniline; trichlorophosphate 16 h; Reflux;
参考文献
Deng, Jifeng; Peng, Li; Zhang, Guicheng; Lan, Xiaobing; Li, Chufang; Chen, Fuxin; Zhou, Yayao; Lin, Zuoxian; Chen, Ling; Dai, Renke; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Hu, Wenhui
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 71 - 76
反应条件
ammonia; zinc in ethanol; water T=78°C; 1 h;
参考文献
Bergman, Jeffrey M.; Breslin, Michael J.; Coleman, Paul J.; Cox, Christopher D.; Mercer, Swati P.; Roecker, Anthony J.
Patent: US2008/132490 A1, 2008 ;
Location in patent: Page/Page column 19-20 ;
US 20080132490 A1
反应条件
sodium hydroxide in tetrahydrofuran
T=20°C; 4 h; Inert atmosphere;
参考文献
Deng, Jifeng; Peng, Li; Zhang, Guicheng; Lan, Xiaobing; Li, Chufang; Chen, Fuxin; Zhou, Yayao; Lin, Zuoxian; Chen, Ling; Dai, Renke; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Hu, Wenhui
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 71 - 76