6-溴噻吩并[2,3-D]嘧啶-4(3H)-酮合成路线 （共 9 条）
反应条件
bromine; acetic acid T=20°C; 4 h;
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; MARUGAN, Juan, J.; ZHENG, Wei; SOUTHALL, Noel; HUANG, Wenwei; MCCOY, Joshua, G.; TITUS, Steven; PATNAIK, Samarjit
Patent: WO2012/44993 A1, 2012 ;
Location in patent: Page/Page column 44 ;
反应条件
1: NaOAc / Heating 2: Br2 / acetic acid View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 587 - 591
反应条件
1: Heating 2: Br2 / acetic acid View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 587 - 591
反应条件
1: trichlorophosphate / 3 h / 120 °C 2: tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate / 1,4-dioxane / 5 h / 130 °C View Scheme
参考文献
Tetrahedron, , vol. 68, # 45 p. 9226 - 9233
反应条件
1: trichlorophosphate / 3 h / 120 °C 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane / 24 h / 110 °C View Scheme
参考文献
Tetrahedron, , vol. 68, # 45 p. 9226 - 9233
反应条件
1: trichlorophosphate / 6 h / Reflux 2: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere View Scheme
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; MARUGAN, Juan, J.; ZHENG, Wei; SOUTHALL, Noel; HUANG, Wenwei; MCCOY, Joshua, G.; TITUS, Steven; PATNAIK, Samarjit
Patent: WO2012/44993 A1, 2012 ;
反应条件
trichlorophosphate T=120°C; 3 h;
参考文献
Bugge, Steffen; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bard Helge
Tetrahedron, 2012 , vol. 68, # 45 p. 9226 - 9233
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in 1,4-dioxane; water T=110°C; Suzuki Coupling; 5 h;
参考文献
Bugge, Steffen; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bard Helge
Tetrahedron, 2012 , vol. 68, # 45 p. 9226 - 9233
反应条件
1.1: trichlorophosphate / 6 h / Reflux
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
3.2: 0.33 h
View Scheme
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; MARUGAN, Juan, J.; ZHENG, Wei; SOUTHALL, Noel; HUANG, Wenwei; MCCOY, Joshua, G.; TITUS, Steven; PATNAIK, Samarjit
Patent: WO2012/44993 A1, 2012 ;
