甲基-4-(2-溴乙氧基)苯甲酸合成路线 （共 10 条）
参考文献
Eli Lilly and Company
Patent: US6541499 B1, 2003 ;
US 6541499 B1
反应条件
potassium carbonate in ethyl acetate; butanone
参考文献
US3940407 A1, ;
US 3940407 A
反应条件
phosphorus pentabromide
参考文献
DE412699 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1724
反应条件
1: alkali 2: phosphorus pentabromide View Scheme
参考文献
DE412699 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1724
反应条件
1: 91.7 percent / glacial AcOH, 92percent H2SO4 / 5 h / Heating 2: butan-1-ol / 10 h / Heating View Scheme
参考文献
Kochergin, P. M.; Palei, R. M.; Balandina, L. V.; Kharitonova, A. E.; Kravchenko, A. N.; et al.
Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 2 p. 139 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 2 p. 56 - 57
反应条件
1.1: N,N-dimethyl-formamide / 20 °C 2.1: sodium hydroxide; water / methanol / 2 h / 40 °C 2.2: pH 4 / Acidic conditions View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; CHU, Daniel; WANG, Bing
Patent: WO2011/140009 A1, 2011 ;
反应条件
in N,N-dimethyl-formamide
T=20°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; CHU, Daniel; WANG, Bing
Patent: WO2011/140009 A1, 2011 ;
Location in patent: Page/Page column 98; 99 ;
反应条件
platinum charcoal in methanol; ethanol; water; ethyl acetate
参考文献
Syntex (U.S.A.) Inc.
Patent: US3940407 A1, 1976 ;
US 3940407 A
反应条件
tetra-(n-butyl)ammonium iodide in tetrahydrofuran
参考文献
Eli Lilly and Company
Patent: US6541499 B1, 2003 ;
US 6541499 B1
反应条件
sulfuric acid; acetic acid
5 h; Heating;
参考文献
Kochergin, P. M.; Palei, R. M.; Balandina, L. V.; Kharitonova, A. E.; Kravchenko, A. N.; et al.
Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 2 p. 139 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 2 p. 56 - 57
