N-[苄氧羰基]-L-谷氨酸 5-叔丁酯 1-甲酯合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h; Title compound not separated from byproducts;
参考文献
Van Heerbeek, Rieko; Kamer, Paul C. J.; Van Leeuwen, Piet N.M.W.; Reek, Joost N.H.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 2 p. 211 - 223
反应条件
1: aq. NaOH 2: H2 / Pd View Scheme
参考文献
Schroeder,E.; Klieger,E.
Justus Liebigs Annalen der Chemie, 1964 , vol. 673, p. 196 - 207
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h; Title compound not separated from byproducts;
参考文献
Van Heerbeek, Rieko; Kamer, Paul C. J.; Van Leeuwen, Piet N.M.W.; Reek, Joost N.H.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 2 p. 211 - 223
参考文献
Schroeder,E.; Klieger,E.
Justus Liebigs Annalen der Chemie, 1964 , vol. 673, p. 196 - 207
反应条件
1: 85 percent / H2, AcOH / 5percent Pd/C / methanol / 2280 - 3040 Torr
2: 1.) diethyl phosphorocyanidate, Et3N, 2.) Et3N / 1.) DMF, 80 deg C, 2 min, 2.) DMF, 80 deg C, 2 h
3: 92 percent / Ba(OH)2*8H2O / ethanol; H2O / Ambient temperature
View Scheme
参考文献
Rosowsky, Andre; Forsch, Ronald; Uren, Jack; Wick, Michael
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1450 - 1455
参考文献
Geiger,R. et al.
Chemische Berichte, 1963 , vol. 96, p. 1080 - 1087
Full Text Show Details
Klieger,E.; Gibian,H.
Justus Liebigs Annalen der Chemie, 1962 , vol. 655, p. 195 - 210
