(1R,5S)-8-乙酰基-8-氮杂双环[3.2.1]辛烷-3-酮合成路线 （共 5 条）
反应条件
palladium diacetate
T=80°C; 14 h; Neat (no solvent); Product distribution / selectivity;
参考文献
Brock University
Patent: US2009/5565 A1, 2009 ;
Location in patent: Page/Page column 4; 6 ;
参考文献
SANOFI; BIALY, Laurent; LORENZ, Katrin; WIRTH, Klaus; STEINMEYER, Klaus; HESSLER, Gerhard; PERNERSTORFER, Josef; BRENDEL, Joachim
Patent: WO2013/37914 A1, 2013 ;
Location in patent: Page/Page column 64-65 ;
参考文献
Berdini, Valerio; Cesta, Maria C; Curti, Roberto; D'Anniballe, Gaetano; Bello, Nicoletta Di; Nano, Giuseppe; Nicolini, Luca; Topai, Alessandra; Allegretti, Marcello
Tetrahedron, 2002 , vol. 58, # 28 p. 5669 - 5674
反应条件
1.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 3 h / Heating
1.2: 100 percent / methanol / 5 h / Heating
2.1: 63 percent / 3 h / 70 °C
View Scheme
参考文献
Berdini, Valerio; Cesta, Maria C; Curti, Roberto; D'Anniballe, Gaetano; Bello, Nicoletta Di; Nano, Giuseppe; Nicolini, Luca; Topai, Alessandra; Allegretti, Marcello
Tetrahedron, 2002 , vol. 58, # 28 p. 5669 - 5674
反应条件
zunaechts unter Kuehlung, dann auf dem Wasserbad;
参考文献
Polonovski; Polonovski
Bulletin de la Societe Chimique de France, 1927 , vol. <4> 41, p. 1189
Bulletin de la Societe Chimique de France, 1928 , vol. <4> 43, p. 83
