N-2-[(4-1H-咪唑基)乙基]-3-氨基丙酰胺二盐酸盐合成路线 （共 3 条）
反应条件
1: toluene / 3 h / Heating; Dean-Stark conditions 2: Et3N / acetonitrile / 3 h / 20 °C 3: NH2NH2*H2O / ethanol / 5 h / 20 °C 4: diisopropyl carbodiimide; 1-hydroxybenzotriazole / acetonitrile / 4 °C 5: TFA / CH2Cl2 / 0.17 h / 0 °C 6: aq. HCl / dioxane / 40 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 12 p. 2915 - 2923
反应条件
1: diisopropyl carbodiimide; 1-hydroxybenzotriazole / acetonitrile / 4 °C 2: TFA / CH2Cl2 / 0.17 h / 0 °C 3: aq. HCl / dioxane / 40 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 12 p. 2915 - 2923
反应条件
1: NH2NH2*H2O / ethanol / 5 h / 20 °C 2: diisopropyl carbodiimide; 1-hydroxybenzotriazole / acetonitrile / 4 °C 3: TFA / CH2Cl2 / 0.17 h / 0 °C 4: aq. HCl / dioxane / 40 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 12 p. 2915 - 2923
