1-(2,2-二氟-1-苯基乙烯基)-4-氟苯合成路线 （共 35 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; caesium carbonate in methanol
T=20°C; Suzuki-Miyaura Coupling; 22 h; Inert atmosphere; Reagent/catalystTemperature;
参考文献
Kim, Ju Hee; Choi, Su Jeong; Jeong, In Howa
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2470 - 2475
反应条件
tetrakis(triphenylphosphine) palladium(0); lithium bromide in N,N-dimethyl-formamide
T=100°C; 2 h; Inert atmosphere;
参考文献
Han, Seung Yeon; Jeong, In Howa
Organic Letters, 2010 , vol. 12, # 23 p. 5518 - 5521
反应条件
1: 2,2-difluoro-1-tributylstannylethenyl p-toluenesulfonate With tetrakis(triphenylphosphine) palladium(0); 1,1,1,2,2,2-hexabutyl-distannane; lithium bromide in tetrahydrofuran
4 h; Inert atmosphereReflux;
2: iodobenzene With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=80°C; 3 h; Inert atmosphere;
参考文献
Han, Seung Yeon; Lee, Hyo Young; Jeon, Jong Hee; Jeong, In Howa
Tetrahedron Letters, 2012 , vol. 53, # 14 p. 1833 - 1836
反应条件
tributylphosphine; sodium iodide in tetrahydrofuran
T=70°C; 2 h;
参考文献
Nowak, Ireneusz; Robins, Morris J.
Organic Letters, 2005 , vol. 7, # 4 p. 721 - 724
反应条件
lithium iodide; tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine in tetrahydrofuran; diethyl ether; benzene-d6
T=60°C; P=2625.26 Torr; 2 h; Product distribution / selectivity;
参考文献
Nagai, Takabumi; Shibanuma, Takashi; Ogoshi, Sensuke; Ohashi, Masato
Patent: US2012/330072 A1, 2012 ;
Location in patent: Page/Page column 7 ;
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium tert-butylate; tri-cyclo-hexyl-phosphine in tetrahydrofuran; benzene-d6
T=100°C; 16 h; Inert atmosphere;
参考文献
Daikin Industries; Osaka University; Nagai, Takabumi; Adachi, Kenji; Shibanuma, Takashi; Ogoshi, Sensuke; Ohashi, Masato
Patent: US2013/324757 A1, 2013 ;
Location in patent: Paragraph 0287 ;
反应条件
bis(1,5-cyclooctadiene)nickel (0); caesium carbonate; tri-cyclo-hexyl-phosphine in tetrahydrofuran; benzene-d6
T=100°C; 16 h; Inert atmosphere;
参考文献
Daikin Industries; Osaka University; Nagai, Takabumi; Adachi, Kenji; Shibanuma, Takashi; Ogoshi, Sensuke; Ohashi, Masato
Patent: US2013/324757 A1, 2013 ;
Location in patent: Paragraph 0277-0284 ;
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=80°C; Suzuki-Miyaura coupling reaction; 5 h;
参考文献
Choi, Ji Hoon; Jeong, In Howa
Tetrahedron Letters, 2008 , vol. 49, # 6 p. 952 - 955
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in methanol
T=20°C; Suzuki-Miyaura Coupling; 15 h; Reagent/catalyst;
参考文献
Kim, Ju Hee; Choi, Su Jeong; Jeong, In Howa
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2470 - 2475
反应条件
Na2[PdCl4]; cataCXium F sulf; potassium carbonate in water; butan-1-ol
T=95°C; Suzuki-Miyaura coupling; 16 h; Inert atmosphere;
参考文献
Pschierer, Jan; Peschek, Natalie; Plenio, Herbert
Green Chemistry, 2010 , vol. 12, # 4 p. 636 - 642
