1-(2,2-二氟-1-苯基乙烯基)-4-氟苯合成路线 （共 35 条）
反应条件
lithium diisopropyl amide
1) THF, -50 deg C, 30 min, 2) -50 deg C -> rt, then reflux; Yield given. Multistep reaction;
参考文献
Edwards, Michael L.; Stemerick, David M.; Jarvi, Esa T.
Tetrahedron Letters, 1990 , vol. 31, # 39 p. 5571 - 5574
反应条件
1: 80 percent / aq. NaOH / Ambient temperature
2: 1.) PhSO2Cl, pyridine / 1.) CHCl3, 0-5 deg C, 12 h, 2.) 25 deg C, 12 h
View Scheme
参考文献
Ocampo, Rogelio; Dolbier, William R.; Paredes, Rodrigo
Journal of Fluorine Chemistry, 1998 , vol. 88, # 1 p. 41 - 50
反应条件
1,4-dioxane; potassium hydroxide
参考文献
Kellogg Co.
Patent: US2784176 , 1954 ;
反应条件
1: H2SO4
2: aqueous KOH; dioxane
View Scheme
参考文献
Kellogg Co.
Patent: US2784176 , 1954 ;
反应条件
in tetrahydrofuran
72 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Wheaton, Gregory A.; Burton, Donald J.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 917 - 927
