1-[3-(4-甲基-1-哌嗪)-苯基]-乙酮合成路线 （共 5 条）
反应条件
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); 2-dicyclohexylphosphino-1,1'-biphenyl in ethylene glycol dimethyl ether
T=100°C; Arylation; 21 h;
参考文献
Wolfe, John P.; Tomori, Hiroshi; Sadighi, Joseph P.; Yin, Jingjun; Buchwald, Stephen L.
Journal of Organic Chemistry, 2000 , vol. 65, # 4 p. 1158 - 1174
反应条件
sodium hydroxide; sulfuric acid; Pt/C in ethanol; water; dimethyl sulfoxide; benzene
参考文献
Parke, Davis and Company
Patent: US3954734 A1, 1976 ;
反应条件
1: p-TsOH / toluene / 18 h / Heating
2: Pd2(dba)3; rac-BINAP; NaOtBu / toluene / 18 h / 80 °C
3: aq. HCl / toluene / 2 h / 25 °C
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1: Pd2(dba)3; rac-BINAP; NaOtBu / toluene / 18 h / 80 °C
2: aq. HCl / toluene / 2 h / 25 °C
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1: Pd2(dba)3; rac-BINAP; NaOtBu / toluene / 18 h / 80 °C
2: aq. HCl / toluene / 2 h / 25 °C
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
