1-(2'-甲基[1,1'-联苯]-4-基)乙酮合成路线 （共 22 条）
反应条件
potassium phosphate; water in toluene
T=100°C; Suzuki coupling reaction; 1 h;
参考文献
Hagiwara, Hisahiro; Sato, Kota; Hoshi, Takashi; Suzuki, Toshio
Synlett, 2011 , # 17 p. 2545 - 2550
反应条件
potassium phosphate; palladium-incarcerated polystyrene-based copolymer; tri(2-methoxy-phenyl)-phosphine in water; toluene
Suzuki-Miyaura coupling; 2 h; Heating;
参考文献
Hanhan, Murat Emre; Martinez-Manez, Ramon; Ros-Lis, Jose Vicente
Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2388 - 2391
反应条件
silver tetrafluoroborate; C16H36N(1+)*C32H25Cl2Fe2N2O3PdS(1-); potassium carbonate in water
Suzuki coupling; 0.25 h; Microwave irradiation;
参考文献
Hanhan, Murat Emre; Martinez-Manez, Ramon; Ros-Lis, Jose Vicente
Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2388 - 2391
反应条件
potassium fluoride; tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine in tetrahydrofuran
T=20°C; Suzuki cross-coupling; 3 h;
参考文献
McNulty, James; Capretta, Alfredo; Wilson, Jeff; Dyck, Jeff; Adjabeng, George; Robertson, Al
Chemical Communications, 2002 , # 17 p. 1986 - 1987
反应条件
potassium fluoride; palladium diacetate; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=20°C; Suzuki cross-coupling; 0.5 h;
参考文献
Littke, Adam F.; Dai, Chaoyang; Fu, Gregory C.
Journal of the American Chemical Society, 2000 , vol. 122, # 17 p. 4020 - 4028
反应条件
potassium fluoride; tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine in tetrahydrofuran
T=20°C; Suzuki cross-coupling; 6 h;
参考文献
Littke, Adam F.; Dai, Chaoyang; Fu, Gregory C.
Journal of the American Chemical Society, 2000 , vol. 122, # 17 p. 4020 - 4028
反应条件
K3PO4*7H2O in tetrahydrofuran
T=60°C; Suzuki coupling; 24 h; Inert atmosphere;
参考文献
Wu, Lei; Ling, Jie; Wu, Zong-Quan
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1452 - 1456
反应条件
1: 2-methylphenylmagnesium chloride With zinc(II) chloride in 1-methyl-pyrrolidin-2-one; diethyl ether
T=60°C; 0.333333 h;
2: 4'-iodoacetophenone With ((Cy2POH)2PdCl)2 in 1-methyl-pyrrolidin-2-one
T=65°C; Negishi cross-coupling; 2 h; Further stages.;
参考文献
Xu, Hanhui; Ekoue-Kovi, Kekeli; Wolf, Christian
Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7638 - 7650
反应条件
1: 2-methylphenylmagnesium chloride With zinc(II) chloride in tetrahydrofuran
T=20°C; 0.333333 h;
2: para-chloroacetophenone With Pd0(tris(tert-butyl)phosphine)2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi reaction; 2 h; Further stages.;
参考文献
Dai; Fu
Journal of the American Chemical Society, 2001 , vol. 123, # 12 p. 2719 - 2724
反应条件
sodium hydroxide; Pd(NH3)2Cl2 in water
T=120°C; Hiyama coupling; 18 h;
参考文献
Chen, Shao-Nung; Wu, Wei-Yi; Tsai, Fu-Yu
Tetrahedron, 2008 , vol. 64, # 35 p. 8164 - 8168
