1-(2'-甲基[1,1'-联苯]-4-基)乙酮合成路线 （共 22 条）
反应条件
palladium diacetate in ethanol
T=95°C; 0.25 h; microwave irradiation;
参考文献
Kabalka, George W.; Zhou, Li-Li; Naravane, Abhijit
Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6887 - 6889
反应条件
[(P{(NC5H10)(C6H11)2})2Pd(Cl)2] in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; 0.333333 h; In air;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Chemistry - A European Journal, 2010 , vol. 16, # 36 p. 11072 - 11081
反应条件
morpholine; potassium phosphate; palladium diacetate in isopropyl alcohol
T=80°C; Suzuki-Miyaura Coupling; 14 h; Inert atmosphere;
参考文献
Abe, Taichi; Mino, Takashi; Watanabe, Kohei; Yagishita, Fumitoshi; Sakamoto, Masami
European Journal of Organic Chemistry, 2014 , vol. 2014, # 18 p. 3909 - 3916
反应条件
{C6H3[NHP(piperidinyl)2]2Pd(Cl)}; potassium carbonate in 1,4-dioxane; water; butan-1-ol
T=100°C; Suzuki-Miyaura reaction; 2 h;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 6 p. 1075 - 1080
反应条件
triphenyl phosphite; K3PO4*3H2O; Ipr.HCl; palladium diacetate in tert-butyl alcohol
T=80°C; 6 h; Inert atmosphere;
参考文献
Chen, Xiaofeng; Ke, Haihua; Chen, Yao; Guan, Changwei; Zou, Gang
Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7572 - 7578
反应条件
1: ortho-chlorotoluene With tetrahydroxydiboron; ethanol; (X-phos)palladium(II) phenethylamine chloride; potassium acetate; sodium t-butanolate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl
T=80°C; 2 h; Inert atmosphere;
2: para-chloroacetophenone With potassium carbonate in ethanol; water
T=80°C; Suzuki-Miyaura reaction; 15 h; Inert atmosphere;
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Dreher, Spencer D.
Journal of the American Chemical Society, 2010 , vol. 132, # 50 p. 17701 - 17703
反应条件
1: 2-MeC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: para-bromoacetophenone With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine in acetonitrile
T=20°C; Suzuki cross-coupling; 48 h; Inert atmosphere;
参考文献
Proutiere, Fabien; Schoenebeck, Franziska
Angewandte Chemie - International Edition, 2011 , vol. 50, # 35 p. 8192 - 8195
反应条件
1: potassium carbonate / acetone / 20 °C
2: palladium diacetate; morpholine; potassium phosphate / isopropyl alcohol / 14 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
Abe, Taichi; Mino, Takashi; Watanabe, Kohei; Yagishita, Fumitoshi; Sakamoto, Masami
European Journal of Organic Chemistry, 2014 , vol. 2014, # 18 p. 3909 - 3916
反应条件
1.1: tributoxyborane; magnesium; iodine / tetrahydrofuran / 40 °C / |Inert atmosphere
1.2: 2 h / 20 °C / |Inert atmosphere
2.1: hydrogenchloride / water
3.1: triphenyl phosphite; K3PO4*3H2O; palladium diacetate; Ipr.HCl / tert-butyl alcohol / 6 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
Chen, Xiaofeng; Ke, Haihua; Chen, Yao; Guan, Changwei; Zou, Gang
Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7572 - 7578
