hydrogenchloride in acetone T=20°C; 0.0833333 h;

1: With (S)-[α,α-bis(3,5-bistrifluoromethyl)phenyl]-2-pyrrolidine methanol trimethylsilyl ether; benzoic acid in toluene T=20°C; Michael condensation; 2: With methanesulfonic acid in toluene T=90°C; 0.666667 h; optical yield given as percent eeenantioselective reaction;

potassium hydroxide in pyridine; ethanol T=20°C; electrolysis: C-anode, Pt-catode;

1: 1.) AlCl3 / 1.) CH2Cl2, 0 deg C, 30 min, 2.) CH2Cl2, -20 deg C, 1 h 2: 100 percent / H2 / 10percent Pd/C / benzene / 5 h / 825.07 Torr View Scheme