4-(2,2,2-三氟乙氧基)苯甲腈合成路线 （共 10 条）
反应条件
potassium fluoride in dimethyl sulfoxide T=120 - 130°C; 4 h;
参考文献
Kamal, Ahmed; Pratap; Ramana, K.Venkata; Ramana; Babu, A.Hari
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7353 - 7355
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=150°C; 15 h;
参考文献
Idoux, John P.; Gupton, John T.; McCurry, Cynthia K.; Crews, A. Donald; Jurss, Cindy D.; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 21 p. 3771 - 3773
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=25°C; 20 h;
参考文献
Idoux, John P.; Madenwald, Mark L.; Garcia, Brent S.; Chu, Der-Lun; Gupton, John T.
Journal of Organic Chemistry, 1985 , vol. 50, # 11 p. 1876 - 1878
反应条件
sodium hydride in N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane T=90 - 150°C;
参考文献
Gupton, John T.; Idoux, John P.; Colon, Cesar; Rampi, Rick
Synthetic Communications, 1982 , vol. 12, # 9 p. 695 - 700
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in methanol P=2844.3 Torr; 4 h;
参考文献
Canadian Journal of Chemistry, , vol. 63, p. 3037 - 3042
反应条件
sodium hydride in N,N-dimethyl-formamide Ambient temperature;
参考文献
Zhang, Rong; Qian, Xuhong; Zhou, Weida
Organic Preparations and Procedures International, 1999 , vol. 31, # 1 p. 110 - 111
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=50°C; 20 h;
参考文献
Idoux, John P.; Madenwald, Mark L.; Garcia, Brent S.; Chu, Der-Lun; Gupton, John T.
Journal of Organic Chemistry, 1985 , vol. 50, # 11 p. 1876 - 1878
反应条件
1: 2,2,2-trifluoroethanol With sodium hydride in N,N-dimethyl-formamide 2: 4-fluorobenzenecarbonitrile in N,N-dimethyl-formamide 3 h; Reflux;
参考文献
Riss, Patrick J.; Aigbirhio, Franklin I.
Chemical Communications, 2011 , vol. 47, # 43 p. 11873 - 11875
反应条件
1: 63 percent / hexamethylphosphoric acid triamide / Heating 2: H2, NaOAc / Pd/C / methanol View Scheme
参考文献
Synthetic Communications, , vol. 14, # 7 p. 621 - 630
反应条件
1: 94.6 percent / NH2OH*HCl, HCOOH / H2O / 0.25 h / Heating 2: 95 percent / NaH / dimethylformamide / 1.) r.t., 20 min, 2.) r.t., 1 d View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 31, # 1 p. 110 - 111
