1’-氧代-螺[环己基-1,3’(1’H)-呋喃并[3,4-c]吡啶]-4-羧酸合成路线 （共 1 条）
反应条件
1.1: POCl3; DMF / tetrahydrofuran / 0.17 h / 22 °C 2.1: TMEDA; LiCl; t-butyl alcohol / tetrahydrofuran / 19 h / 35 - 39 °C 2.2: 445 mg / H2SO4 / tetrahydrofuran; H2O / 3 h / 50 °C 3.1: thionyl chloride / N,N-dimethyl-acetamide / 0.67 h / cooling 3.2: 92 percent / pyridine / N,N-dimethyl-acetamide / 1 h / 18 °C View Scheme
参考文献
Iida, Takehiko; Satoh, Hiroki; Maeda, Kenji; Yamamoto, Yuhei; Asakawa, Ken-Ichi; Sawada, Naotaka; Wada, Toshihiro; Kadowaki, Chie; Itoh, Takahiro; Mase, Toshiaki; Weissman, Steven A.; Tschaen, Dave; Krska, Shane; Volante
Journal of Organic Chemistry, 2005 , vol. 70, # 23 p. 9222 - 9229
