5-(苄氧基)-2-羟基苯甲醛合成路线 （共 17 条）
反应条件
1: potassium carbonate / acetonitrile / |Reflux
2: MgBr2(Et2O) / benzene; diethyl ether / |Inert atmosphere; |Reflux
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
参考文献
Kappe Th.; Witoszynskyj Th.
Archiv der Pharmazie, 1975 , vol. 308, # 5 p. 339 - 346
反应条件
triethylamine; magnesium chloride
参考文献
Zagol-Ikapitte, Irene; Amarnath, Venkataraman; Bala, Manju; Roberts II, L. Jackson; Oates, John A.; Boutaud, Olivier
Chemical Research in Toxicology, 2010 , vol. 23, # 1 p. 240 - 250
反应条件
bromine; sodium acetate; acetic acid
T=20°C; 3 h;
参考文献
Hayashi, Ken-ichiro; Yamazoe, Atsushi; Ishibashi, Yuki; Kusaka, Naoyuki; Oono, Yutaka; Nozaki, Hiroshi
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 9 p. 5331 - 5344
反应条件
1.1: potassium carbonate / acetonitrile / 60 h / |Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere
3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / |Inert atmosphere
3.2: 20 °C
4.1: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / |Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
1: potassium carbonate / acetonitrile / 60 h / |Reflux
2: hydrogen; palladium on activated charcoal / ethanol / 20 °C
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
1: aq. NaOH
2: (i) aq. NaHSO3, (ii) /BRN= 1718733/, HCl, Et2O, (iii) H2O
3: aq. NaOH
4: LiAlH4 / diethyl ether
5: H2 / Pd-C / ethanol
View Scheme
参考文献
Kappe Th.; Witoszynskyj Th.
Archiv der Pharmazie, 1975 , vol. 308, # 5 p. 339 - 346
