2-苯基吡唑并(1,5-a)喹啉合成路线 （共 18 条）
反应条件
1: 1.) SnCl2, conc. HCl; 2.) 2.5percent HCl / 1.) 15 h; 2.) reflux, 5 min
2: 15.5 g / p.toluenesulfonic acid / benzene / 6 h / Heating
3: Na / various solvent(s) / 1 h / Heating
4: 83 percent / NaOH / ethanol / 2.5 h / Heating
5: sulfur / neat (no solvent) / 1 h / 260 °C
View Scheme
参考文献
Winters; Odasso; Conti; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 3 p. 215 - 218
反应条件
1: 83 percent / NaOH / ethanol / 2.5 h / Heating
2: sulfur / neat (no solvent) / 1 h / 260 °C
View Scheme
参考文献
Winters; Odasso; Conti; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 3 p. 215 - 218
反应条件
1: 36 percent / toluene / 18 h / 105 °C
2: 90 percent / 57percent hydroiodic acid / 3 h / Heating
View Scheme
参考文献
Sundberg, Richard J.; Ellis, James E.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 573 - 576
反应条件
1: 80 percent / K2CO3 / CH2Cl2 / 12 h
2: 36 percent / toluene / 18 h / 105 °C
3: 90 percent / 57percent hydroiodic acid / 3 h / Heating
View Scheme
参考文献
Sundberg, Richard J.; Ellis, James E.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 573 - 576
反应条件
1: 36 percent / toluene / 18 h / 105 °C
2: 90 percent / 57percent hydroiodic acid / 3 h / Heating
View Scheme
参考文献
Sundberg, Richard J.; Ellis, James E.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 573 - 576
反应条件
1: 48 percent / NH2OH*HCl, NaOAc / methanol; H2O / 1 h / Heating
2: 22 percent / O-mesitylsulphonylhydroxylamine / CHCl3 / 1 h / 25 °C
View Scheme
参考文献
Gnichtel, Horst; Moeller, Bernd
Liebigs Annalen der Chemie, 1981 , # 10 p. 1751 - 1759
反应条件
1.1: O-(2,4-dinitro-phenyl)-hydroxylamine / tetrahydrofuran; water / 16 h / 40 °C / Inert atmosphere
2.1: tetrahydrofuran; water / 0.5 h / Inert atmosphere
2.2: Inert atmosphere
3.1: palladium bromide; tris(4-methoxyphenyl)-phosphine; silver benzoate / 1,4-dioxane / 16 h / 125 °C / Inert atmosphere
View Scheme
参考文献
Mousseau, James J.; Bull, James A.; Ladd, Carolyn L.; Fortier, Angelique; Sustac Roman, Daniela; Charette, Andre B.
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8243 - 8261
反应条件
O-(2,4,6-trimethylbenzenesulfonyl)hydroxylamine; potassium carbonate
2.) DMF, r.t.; Yield given. Multistep reaction;
参考文献
Tsuchiya, Takashi; Sashida, Haruki
Journal of the Chemical Society, Chemical Communications, 1980 , # 23 p. 1109 - 1110
