5-氯-4-乙氧羰基-1-甲基吡唑合成路线 (共 4 条)
反应条件
1: With tert.-butylnitrite; copper(l) chloride in acetonitrile T=0 - 65°C; 2.5 h; 2: With hydrogenchloride in water; acetonitrile
参考文献
Anderson, Kevin William; Fotouhi, Nader; Gillespie, Paul; Goodnow, Robert Alan; Guertin, Kevin Richard; Haynes, Nancy-Ellen; Myers, Michael Paul; Pietranico-Cole, Sherrie Lynn; Qi, Lida; Rossman, Pamela Loreen; Scott, Nathan Robert; Thakkar, Kshitij Chhabilbhai; Tilley, Jefferson Wright; Zhang, Qiang
Patent: US2007/225280 A1, 2007 ;
Location in patent: Page/Page column 18 ;
US 20070225280 A1
参考文献
EP1953145 A1, ;
Page/Page column 21-22 ;
反应条件
hydrogenchloride; sodium nitrite; copper(l) chloride 1) < 10 deg C, 10 min, 2) room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 28, # 6 p. 1545 - 1547
反应条件
potassium hydroxide in ethanol