4,5-二氯-2-硝基苯甲醛合成路线 （共 7 条）
反应条件
ammonium hydroxide in ethanol; water
参考文献
Astra AB
Patent: US5710139 A1, 1998 ;
US 5710139 A
反应条件
manganese(IV) oxide in chloroform
18 h; Heating / reflux;
参考文献
Active Biotech AB
Patent: US2005/192288 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
1: With N,N-dimethyl-formamide dimethyl acetal
T=140°C; 24 h; RefluxInert atmosphere;
2: With sodium periodate in water; N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
Ramalingam, Bose Muthu; Saravanan, Velu; Mohanakrishnan, Arasambattu K.
Organic Letters, 2013 , vol. 15, # 14 p. 3726 - 3729
反应条件
1: 83.6 percent / BH3*THF / tetrahydrofuran / Ambient temperature
2: 1.) NaNO2, AcOH, 2.) NaOH / 1.) H2O, 0 deg C, 10 min, rt, 15 min, 2.) MeOH, H2O, rt, 10 min
3: 80 percent / PCC / CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Zhu, Zhijian; Lippa, Blaise; Townsend, Leroy B.
Journal of Organic Chemistry, 1999 , vol. 64, # 11 p. 4159 - 4168
反应条件
1: 1.) t-BuONO, BF3*Et2O, 2.) CuCN / 1.) THF, CH2Cl2, -10 deg C, 2.) H2O, rt, overnight
2: 83.6 percent / BH3*THF / tetrahydrofuran / Ambient temperature
3: 1.) NaNO2, AcOH, 2.) NaOH / 1.) H2O, 0 deg C, 10 min, rt, 15 min, 2.) MeOH, H2O, rt, 10 min
4: 80 percent / PCC / CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Zhu, Zhijian; Lippa, Blaise; Townsend, Leroy B.
Journal of Organic Chemistry, 1999 , vol. 64, # 11 p. 4159 - 4168
反应条件
1: 1.) NaNO2, AcOH, 2.) NaOH / 1.) H2O, 0 deg C, 10 min, rt, 15 min, 2.) MeOH, H2O, rt, 10 min
2: 80 percent / PCC / CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Zhu, Zhijian; Lippa, Blaise; Townsend, Leroy B.
Journal of Organic Chemistry, 1999 , vol. 64, # 11 p. 4159 - 4168
参考文献
Hoechster Farbw.
Patent: DE254467 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 289
