反应条件
1.1: potassium carbonate; sodium periodate; potassium permanganate / tert-butyl alcohol; water / 1 h / 50 °C 2.1: triethylamine / tetrahydrofuran / 2 h / -5 - -2 °C / |Inert atmosphere 3.1: ammonium acetate / tetrahydrofuran / 1 h / |Reflux; |Inert atmosphere 4.1: hydrogenchloride / water; tetrahydrofuran / 1 h / -15 - 0 °C 5.1: hydrogen; palladium 10 on activated carbon; triethylamine / 6225.62 Torr 6.1: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C 7.1: hydrogenchloride / methanol / 3 h / 20 °C / |Reflux 8.1: N,N,N',N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.5 h / -10 °C / |Inert atmosphere 8.2: 2 h / -10 - 0 °C 9.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.33 h / -15 °C 9.2: 2 h / 50 °C View Scheme
参考文献
RICHTER GEDEON NYRT.; SÖRÖS, Béla; TUBA, Zoltán; GÁLIK, György; MAHÓ, Sándor; BALOGH, László; VINCZE, Péter; HORVÁTH, János; KOVÁCS, András; BÉNI, Zoltán; VARGA, Frigyes
Patent: WO2013/1322 A1, 2013 ;
