2,4,6-三甲氧基苯甲酸合成路线 （共 21 条）
反应条件
sulfuric acid 24 h; Reflux;
参考文献
Indicator Systems International, Inc.; Gorski, Joel R.; Booher, Jon; Sabnis, Ram W.
Patent: US8425996 B2, 2013 ;
Location in patent: Page/Page column 18; 19 ;
参考文献
Herzig; Wenzel; Gehringer
Monatshefte fuer Chemie, 1903 , vol. 24, p. 866
反应条件
1: With palladium (II) trifluoroacetate; 6-mbipy in water T=130°C; 1 h; Microwave irradiation; 2: With formic acid in water T=100°C; 1 h;
参考文献
Lindh, Jonas; Sjoeberg, Per J. R.; Larhed, Mats
Angewandte Chemie - International Edition, 2010 , vol. 49, # 42 p. 7733 - 7737
反应条件
palladium (II) trifluoroacetate; trifluoroacetic acid in dimethyl sulfoxide; N,N-dimethyl-formamide T=70°C; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 78, # 10 p. 4744 - 4761
反应条件
[Rh(OH)(cycloocta-1,5-diene)]2; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium hydroxide in water; toluene T=120°C; 24 h; Inert atmosphere;
参考文献
Angewandte Chemie, International Edition, , vol. 48, # 36 p. 6726 - 6730
Angewandte Chemie, , vol. 121, # 36 p. 6854 - 6858
反应条件
(4R,5R)-DIOP; [Rh(OH)(cycloocta-1,5-diene)]2; water; sodium hydroxide in toluene T=120°C; Heck-Mizoroki olefination; 30 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 12, # 5 p. 992 - 995
反应条件
silver carbonate; copper(ll) bromide; palladium dichloride in tetrahydrofuran T=110°C; 24 h;
参考文献
Peng, Xuefeng; Shao, Xiang-Feng; Liu, Zhong-Quan
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3079 - 3081
反应条件
silver carbonate; copper dichloride; palladium dichloride in tetrahydrofuran
T=110°C; 24 h;
参考文献
Peng, Xuefeng; Shao, Xiang-Feng; Liu, Zhong-Quan
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3079 - 3081
反应条件
1: 1-bromo-2,4-dimethoxy-benzene With n-butyllithium in diethyl ether; hexane
T=20°C; 0.166667 h; Inert atmosphereCooling with ice;
2: 2,4,6-trimethoxy benzoic acid in diethyl ether; hexane
0.05 h;
参考文献
Indicator Systems International, Inc.; Gorski, Joel R.; Booher, Jon; Sabnis, Ram W.
Patent: US8425996 B2, 2013 ;
Location in patent: Page/Page column 19 ;
反应条件
trichlorophosphate
4 h; Heating;
参考文献
Robertson; Beedle; Krushinski; Pollock; Wilson; Wyss; Hayes
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 717 - 727
