2-甲基-6-硝基苯胺合成路线 （共 113 条）
反应条件
1: 60 percent / N-bromosuccinimide / CCl4 2: 64 percent / NaNO2; AcOH View Scheme
参考文献
Rakib; Benchidmi; Essassi; El Bouadili; Ibn Mansour; Bellan; Lopez; Lamande
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 5 p. 339 - 345
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite in 1,4-dioxane; water T=0 - 60°C;
参考文献
Holzwarth, Richard; Bartsch, Richard; Cherkaoui, Zoubair; Solladie, Guy
European Journal of Organic Chemistry, 2005 , # 16 p. 3536 - 3541
反应条件
1: 83.7 percent / 12.5 h / 120 °C 2: 85 percent / cc HCl / acetic acid / 1.5 h / Ambient temperature View Scheme
参考文献
Tanaka, Kenjiro; Shimazaki, Michiko; Murakami, Yasuoki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 8 p. 2714 - 2722
参考文献
James; Kenner; Stubbings
Journal of the Chemical Society, 1920 , vol. 117, p. 775
反应条件
1: sulfuric acid 2: permanganate; magnesium sulfate / 100 °C 3: sulfuric acid View Scheme
参考文献
James; Kenner; Stubbings
Journal of the Chemical Society, 1920 , vol. 117, p. 775
反应条件
1: 1.) 6M HCl, NaNO2 / 1.) glacial AcOH, H2O, -10 deg C, 30 min, 2.) H2O, C6H6, 25 deg C, 1 h; 70-75 deg C, 1 h 2: Fe / acetic acid; H2O / 0.25 h / Heating View Scheme
参考文献
Boger, Dale L.; Kochanny, Monica J.; Cai, Hui; Wyatt, Diane; Kitos, Paul A.; Warren; Ramcharan; Gooljarsingh, Lata T.; Benkovic, Stephen J.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 6 p. 643 - 659
反应条件
1: 58 percent / Sn, concd. hydrochloric acid / H2O / 2.5 h / Heating 2: 74 percent / N-thionylaniline / toluene / 3 h / 80 - 100 °C 3: 71 percent / N-bromosuccinimide / CCl4 / 3 h / Heating; Irradiation 4: 68 percent / Li salt of 2-nitropropane / methanol / 24 h / Ambient temperature View Scheme
参考文献
Vanelle, Patrice; Liegeois, Celine Tremblais; Meuche, Jacobine; Maldonado, Jose; Crozet, Michel P.
Heterocycles, 1997 , vol. 45, # 5 p. 955 - 962
反应条件
1: 98 percent / aq. NaNO2; glacial acetic acid / 0.33 h 2: 75 percent / NH4(+)HCOO(-); H2 / Pd/C / ethanol 3: 71 percent / HCl; H2SO4; NaNO2 / KI / 0 °C 4: 79 percent / NBS; NaOH / dimethylformamide / 48 h / 20 °C 5: 53 percent / dppf; Zn / Pd2(dba)3 / N,N-dimethyl-acetamide / 5 h / Heating View Scheme
参考文献
Cottyn, Betty; Vichard, Dominique; Terrier, Francois; Nioche, Pierre; Raman
Synlett, 2007 , # 8 p. 1203 - 1206
反应条件
1: 98 percent / aq. NaNO2; glacial acetic acid / 0.33 h 2: 75 percent / NH4(+)HCOO(-); H2 / Pd/C / ethanol 3: 71 percent / HCl; H2SO4; NaNO2 / KI / 0 °C View Scheme
参考文献
Cottyn, Betty; Vichard, Dominique; Terrier, Francois; Nioche, Pierre; Raman
Synlett, 2007 , # 8 p. 1203 - 1206
反应条件
1: 65 percent / N-chlorosuccinimide / CCl4 2: 72 percent / NaNO2; AcOH 3: 91 percent / H2 / Pd/C / ethanol View Scheme
参考文献
Rakib; Benchidmi; Essassi; El Bouadili; Ibn Mansour; Bellan; Lopez; Lamande
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 5 p. 339 - 345
