2-甲基-6-硝基苯胺合成路线 （共 113 条）
反应条件
1: aq. HCl; SnCl2 2: 65 percent / thionyl chloride / benzene / 72 h 3: 86 percent / bromine; aq. HBr / 16 h / Heating 4: 97 percent / NBS; benzoyl peroxide; HBr / CCl4; acetic acid / 0.5 h / Heating View Scheme
参考文献
Jorgensen, Mikkel; Krebs, Frederik C.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6004 - 6017
反应条件
indium; acetic acid in ethyl acetate 2.5 h; RefluxInert atmosphere;
参考文献
Kim, Jaeho; Kim, Jihye; Lee, Hyunseung; Lee, Byung Min; Kim, Byeong Hyo
Tetrahedron, 2011 , vol. 67, # 41 p. 8027 - 8033
反应条件
1: Diazotization.Behandlung der Diazoniumloesung mit CuCl 2: bei der Reduktion View Scheme
参考文献
Wynne; Greeves
P. Ch. S., p. 154
反应条件
calcium carbonate; benzene
参考文献
Ryan; Cullinane
Scientific Proceedings of the Royal Dublin Society, 1922 , vol. 17, p. 123
Chem.Abstr., vol. 17, p. 1792
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=760.051 Torr; 4 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1479681 A1, 2004 ;
Location in patent: Page 110 ;
参考文献
Gabriel; Thieme
Chemische Berichte, 1919 , vol. 52, p. 1083
参考文献
Lellmann
Justus Liebigs Annalen der Chemie, 1885 , vol. 228, p. 243
反应条件
hydrogen bromide; dihydrogen peroxide in ethanol; water T=60°C; 1 h; Product distribution / selectivity;
参考文献
LONZA LTD; BUeCHNER, Thomas; DRESSEL, Martina; HANSELMANN, Paul; KAISER, Rafael; KLEGRAF, Ellen; ZARAGOZA DOeRWALD, Florencio; DING, Zunliang; WONG, Heilam
Patent: WO2010/81670 A2, 2010 ;
Location in patent: Page/Page column 24 ;
反应条件
ueber 2-Chlor-3-nitro-toluol und 2-Chlor-3-amino-toluol;
参考文献
Cohen; Raper
Journal of the Chemical Society, 1904 , vol. 85, p. 1269
反应条件
1: man ersetzt die NH2-Gruppe durch Brom, reduziert mit Zinn und Salzsaeure und ersetzt die neugebildete NH2-Gruppe durch Chlor 2: HNO3 View Scheme
参考文献
Cohen; Raper
Journal of the Chemical Society, 1904 , vol. 85, p. 1269
