1-苯基-1,2-乙二胺合成路线 （共 28 条）
反应条件
1.1: ethanol / 2 h / Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Cooling with ice; Reflux 2.2: 0 °C View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong
Patent: WO2012/171506 A1, 2012 ;
WO 2012/171506 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
P=1758.35 Torr; 4 h; Product distribution / selectivity;
参考文献
Garst, Michael E.; Dolby, Lloyd Jay; Esfandiari, Shervin; Avey, Alfred Arthur
Patent: US2006/122400 A1, 2006 ;
Location in patent: Page/Page column 5-6; 8 ;
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Arpesella et al.
Gazzetta Chimica Italiana, 1955 , vol. 85, p. 1354,1361
反应条件
1: With diisobutylaluminium hydride in dichloromethane
T=-10 - -5°C; 0.75 h;
2: With sodium hydroxide; water in dichloromethane
T=20°C; 1 h; Product distribution / selectivity;
参考文献
Garst, Michael E.; Dolby, Lloyd Jay; Esfandiari, Shervin; Avey, Alfred Arthur
Patent: US2006/122400 A1, 2006 ;
Location in patent: Page/Page column 6; 8 ;
反应条件
hydrogenchloride; barium carbonate
T=60°C; 7 h;
参考文献
Zhao, Baoguo; Yuan, Weicheng; Du, Haifeng; Shi, Yian
Organic Letters, 2007 , vol. 9, # 24 p. 4943 - 4945
反应条件
sodium hydroxide; ethanol; platinized.Raney nickel
Hydrogenation;
参考文献
Ser; Piaux; Freon
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1949 , vol. 229, p. 376,377
反应条件
lithium aluminium tetrahydride in diethyl ether
Ambient temperature;
参考文献
Shatzmiller, Shimon; Bercovici, Sorin
Liebigs Annalen der Chemie, 1992 , # 10 p. 1005 - 1010
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in toluene
T=0 - 85°C; 15 h;
参考文献
Souto, Jose A.; Gonzalez, Yolanda; Iglesias, Alvaro; Zian, Debora; Lishchynskyi, Anton; Muniz, Kilian
Chemistry - An Asian Journal, 2012 , vol. 7, # 5 p. 1103 - 1111
反应条件
1: NaHCO3 / tetrahydrofuran / Ambient temperature
2: H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Imagawa, Kiyomi; Hata, Eiichiro; Yamada, Tohru; Mukaiyama, Teruaki
Chemistry Letters, 1996 , # 4 p. 291 - 292
反应条件
hydrogen; platinum(IV) oxide in ethanol
参考文献
Minisci,F. et al.
Gazzetta Chimica Italiana, 1964 , vol. 94, p. 67 - 90
