1-苯基-1,2-乙二胺合成路线 （共 28 条）
反应条件
1: NaN3, KMnO4 / methanol
2: H2 / PtO2 / ethanol
View Scheme
参考文献
Minisci,F. et al.
Gazzetta Chimica Italiana, 1964 , vol. 94, p. 67 - 90
反应条件
1: NH2OH
2: H2 / Pd-C / acetic acid
3: aq. HBr / acetic acid
View Scheme
参考文献
Gullotti,M. et al.
Gazzetta Chimica Italiana, 1972 , vol. 102, p. 855 - 892
反应条件
sodium hydroxide in water
Heating;
参考文献
Wada,Y.; Oda,R.
Bulletin of the Chemical Society of Japan, 1970 , vol. 43, p. 2167 - 2173
反应条件
1: 85 percent / NaN3 / methanol; H2O / 18 h / Ambient temperature
2: 85 percent / LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Shatzmiller, Shimon; Bercovici, Sorin
Liebigs Annalen der Chemie, 1992 , # 10 p. 1005 - 1010
反应条件
1.1: ammonium hydroxide / water / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Cooling with ice; Reflux
2.2: 0 °C
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong
Patent: WO2012/171506 A1, 2012 ;
WO 2012/171506 A1
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Dornow et al.
Chemische Berichte, 1957 , vol. 90, p. 2124,2127
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Dornow et al.
Chemische Berichte, 1957 , vol. 90, p. 2124,2127
反应条件
hydrogenchloride
Heating;
参考文献
Graf,R.
Justus Liebigs Annalen der Chemie, 1963 , vol. 661, p. 111 - 157
反应条件
1: ammonia
2: zinc; hydrochloric acid
View Scheme
参考文献
Ruggeri; Rigoli
Gazzetta Chimica Italiana, 1924 , vol. 54, p. 552
参考文献
Ruggeri; Rigoli
Gazzetta Chimica Italiana, 1924 , vol. 54, p. 552
