6-氧代-1,6-二氢-2,3-吡嗪二甲腈合成路线 （共 9 条）
反应条件
1: 26 percent / 10percent Na2CO3 / 8 h / Heating 2: 61 percent / nitrobenzene / 3 h / 170 - 180 °C 3: 77 percent / 10percent NaOH / H2O / 3 h / Heating 4: 64 percent / SOCl2 / 2 h / Heating 5: 68 percent / POCl3, DMF / 2 h / Heating View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 26 percent / 10percent Na2CO3 / 8 h / Heating 2: 61 percent / nitrobenzene / 3 h / 170 - 180 °C 3: 77 percent / 10percent NaOH / H2O / 3 h / Heating 4: 64 percent / SOCl2 / 2 h / Heating View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
hydrogenchloride Ambient temperature;
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 26 percent / 10percent Na2CO3 / 8 h / Heating 2: 61 percent / nitrobenzene / 3 h / 170 - 180 °C View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 30 percent / conc. HCl / Ambient temperature 2: 1.) 10percent NaOH; 2.) SOCl2 / 1.) reflux, 5 h; 2.) reflux, 3 h 3: 5 h / Heating 4: 56 percent / nitrobenzene / 7 h / 180 - 190 °C View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
pyridine; trichlorophosphate
T=90°C; 2 h;
参考文献
Kyowa Gas Chemical Industry Co. Ltd.
Patent: US4259489 A1, 1981 ;
反应条件
1: 77 percent / POCl3, pyridine / 2 h / 90 °C
2: 40 percent / 0 °C
View Scheme
参考文献
Nakamura, Akira; Ataka, Toshiei; Segawa, Hirozo; Takeuchi, Yasutomo; Takematsu, Tetsuo
Agricultural and Biological Chemistry, 1983 , vol. 47, # 7 p. 1555 - 1560
反应条件
1: 30 percent / conc. HCl / Ambient temperature
2: 1.) 10percent NaOH; 2.) SOCl2 / 1.) reflux, 5 h; 2.) reflux, 3 h
View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 26 percent / 10percent Na2CO3 / 8 h / Heating
2: 61 percent / nitrobenzene / 3 h / 170 - 180 °C
3: 77 percent / 10percent NaOH / H2O / 3 h / Heating
4: 64 percent / SOCl2 / 2 h / Heating
5: 68 percent / POCl3, DMF / 2 h / Heating
6: 6 percent / MCPBA / 1,2-dichloro-ethane / 39 h / 65 °C
7: 10 percent / NaOH / H2O / 5 h / 70 - 80 °C
View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
