5-甲基-6-氧代-1,6-二氢吡嗪-2,3-二甲腈合成路线 （共 6 条）
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 78 percent / conc. HCl / 4 h / Heating 2: 75 percent / SOCl2 / 2 h / Heating 3: 77 percent / POCl3, DMF / 2 h / Heating View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 82 percent / POCl3, pyridine / 2 h / 90 °C
2: 81 percent / acetone / 1 h / 10 °C
View Scheme
参考文献
Nakamura, Akira; Ataka, Toshiei; Segawa, Hirozo; Tekeuchi, Yasutomo; Takematsu, Tetsuo
Agricultural and Biological Chemistry, 1983 , vol. 47, # 7 p. 1561 - 1568
反应条件
pyridine; trichlorophosphate
T=90°C; 2 h;
参考文献
Nakamura, Akira; Ataka, Toshiei; Segawa, Hirozo; Tekeuchi, Yasutomo; Takematsu, Tetsuo
Agricultural and Biological Chemistry, 1983 , vol. 47, # 7 p. 1561 - 1568
反应条件
1: 78 percent / conc. HCl / 4 h / Heating
2: 75 percent / SOCl2 / 2 h / Heating
View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 78 percent / conc. HCl / 4 h / Heating
2: 75 percent / SOCl2 / 2 h / Heating
3: 77 percent / POCl3, DMF / 2 h / Heating
4: 9 percent / MCPBA / 1,2-dichloro-ethane / 39 h / 65 °C
5: 67 percent / K2CO3 / H2O / 2 h / Ambient temperature
6: 30 percent / 1 N NaOH / 2 h / Heating
View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
