3-乙酰基-4-羟基苯甲酸甲酯合成路线 （共 12 条）
反应条件
1: With pyridine; bromine in dichloromethane T=0 - 20°C; 2 h; 2: With hydrogenchloride in dichloromethane; water T=5°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BARLAAM, Bernard, Christophe; DEGORCE, Sebastien Louis; LAMBERT-VAN DER BREMPT, Christine Marie Paul; LOHMANN, Jean-Jacques Marcel; PLE, Patrick
Patent: WO2012/140419 A1, 2012 ;
Location in patent: Page/Page column 87-88 ;
反应条件
1: With triethylamine; [Fe(II)(C5H5)(C5H4PPh2)]; palladium diacetate in diethyl ether; ethanol
T=70°C; Inert atmosphere;
2: With hydrogenchloride; water in dichloromethane
2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BARLAAM, Bernard, Christophe; DEGORCE, Sebastien Louis; LAMBERT-VAN DER BREMPT, Christine Marie Paul; LOHMANN, Jean-Jacques Marcel; PLE, Patrick
Patent: WO2012/140419 A1, 2012 ;
Location in patent: Page/Page column 87 ;
反应条件
palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; triethylamine
T=100°C;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
反应条件
sulfuric acid
1 h; Reflux;
参考文献
Chakor, Jyotsna N.; Merlini, Lucio; Dallavalle, Sabrina
Tetrahedron, 2011 , vol. 67, # 34 p. 6300 - 6307
反应条件
1.1: bromine / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / palladium diacetate; [Fe(II)(C5H5)(C5H4PPh2)] / diethyl ether; ethanol / 70 °C / Inert atmosphere
2.2: 2 h
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2011/98271 A1, 2011 ;
反应条件
sodium methylate in methanol
3 h; Heating;
参考文献
Hirota, Kosaku; Kitade, Yukio; Senda, Shigeo
Journal of Organic Chemistry, 1981 , vol. 46, # 20 p. 3949 - 3953
反应条件
in benzene
48 h; Heating;
参考文献
Tsuge, Otohiko; Kanemasa, Shuji; Sakoh, Hirohiko; Wada, Eiji
Chemistry Letters, 1984 , p. 273 - 276
反应条件
carbon disulfide; aluminium trichloride
Erhitzen des vom Schwefelkohlenstoff befreiten Reaktionsgemisches auf 160grad;
参考文献
Rohmann; Wilm
Archiv der Pharmazie (Weinheim, Germany), 1942 , vol. 280, p. 76,82
反应条件
1: AlCl3, aluminium chloride / 5 h / 155 - 160 °C
2: sulfuric acid / 1 h / Reflux
View Scheme
参考文献
Chakor, Jyotsna N.; Merlini, Lucio; Dallavalle, Sabrina
Tetrahedron, 2011 , vol. 67, # 34 p. 6300 - 6307
反应条件
(i) aq. NaNO2, H2SO4, EtOH, (ii) Cu; Multistep reaction;
参考文献
Baker,S.R. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 677 - 685
