3-氯-4-羟基苯乙酸甲酯合成路线 （共 11 条）
反应条件
sulfuric acid in methanol T=68°C; 15 h;
参考文献
GALDERMA RESEARCH and DEVELOPMENT
Patent: US2010/144884 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
sulfuric acid 8 h; Heating;
参考文献
Epple, Robert; Russo, Ross; Azimioara, Mihai; Cow, Christopher; Xie, Yongping; Wang, Xing; Wityak, John; Karanewsky, Don; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 16 p. 4376 - 4380
反应条件
hydrogenchloride in methanol; ethyl acetate
参考文献
Tang, Qing; Maltais, Francois; Janetka, James Walter; Hale, Michael Robin
Patent: US2003/139452 A1, 2003 ;
US 20030139452 A1
Title/Abstract Full Text Show Details
Hale, Michael Robin; Janetka, James Walter; Maltais, Francois; Tang, Qing
Patent: US2003/144337 A1, 2003 ;
US 20030144337 A1
反应条件
methanol in hexane; benzene T=25°C; 1.5 h; Inert atmosphere;
参考文献
Perez-Rodriguez, Santiago; Ortiz, Maria A.; Pereira, Raquel; Rodriguez-Barrios, Fatima; de Lera, Angel R.; Piedrafita, F. Javier
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2434 - 2446
反应条件
1: HCl, As2O3 3: (i) aq. HBr, (ii) /BRN= 1098229/, HCl View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 5 p. 1723 - 1735
反应条件
2: (i) aq. HBr, (ii) /BRN= 1098229/, HCl View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 5 p. 1723 - 1735
反应条件
(i) aq. HBr, (ii) /BRN= 1098229/, HCl; Multistep reaction;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 5 p. 1723 - 1735
反应条件
hydrogenchloride in methanol 24 h; Ambient temperature;
参考文献
Liebigs Annalen der Chemie, , # 8 p. 789 - 798
反应条件
1.1: 95 percent / Et3N / CH2Cl2 / 1 h / 0 °C
2.1: 70 percent / Pd(Ph3P)4 / dimethylformamide / 30 h / 80 °C
3.1: 55 percent / HCO2H / Raney-Ni / 10 h / 110 °C
4.1: 90 percent / NH2OH*HCl; Na2CO3 / H2O / 2 h / 20 °C
5.1: NCS; HCl / dimethylformamide / 0.5 h / 20 °C
6.1: KN(TMS)2; Et3N / diethyl ether / 1 h / 20 °C
6.2: Et3N / acetonitrile / 3 h / 0 °C
7.1: 100 percent / TFA / 4 h / 20 °C
View Scheme
参考文献
Epple, Robert; Russo, Ross; Azimioara, Mihai; Cow, Christopher; Xie, Yongping; Wang, Xing; Wityak, John; Karanewsky, Don; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 16 p. 4376 - 4380
反应条件
1: 95 percent / Et3N / CH2Cl2 / 1 h / 0 °C
2: 70 percent / Pd(Ph3P)4 / dimethylformamide / 30 h / 80 °C
View Scheme
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2013/45447 A1, 2013 ;
