1-甲基-1H-1,2,4-三唑-3-甲酸甲酯合成路线 (共 2 条)
反应条件
1: 1H-[1,2,4]triazole-3-carboxylic acid methyl ester With sodium hydride in tetrahydrofuran 7 h; RefluxInert atmosphere; 2: methyl iodide in tetrahydrofuran T=20°C; Reflux;
参考文献
WO2009/147188 A1, ;
Page/Page column 101-102 ;
WO 2009/147188 A1
反应条件
1: With water; potassium hydroxide in methanol
T=20°C; 3 h;
2: With acetic acid in methanol; N,N-dimethyl-formamide
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/147188 A1, 2009 ;
Location in patent: Page/Page column 102 ;
WO 2009/147188 A1