4-(4-氯-2-噻吩基)-2-噻唑胺合成路线 （共 3 条）
反应条件
1: 2-acetyl-4-chlorothiophene With bromine in diethyl ether
T=0 - 20°C; 2 h;
2: thiourea in ethanol
T=20 - 80°C;
参考文献
Astellas Pharma Inc.
Patent: EP1647553 A1, 2006 ;
Location in patent: Page/Page column 18 ;
反应条件
in ethanol
T=20 - 80°C;
参考文献
YAMANOUCHI PHARMACEUTICAL CO. LTD.
Patent: EP1466912 A1, 2004 ;
Location in patent: Page 16 ;
反应条件
pyridine in tetrahydrofuran
T=20°C; 1.5 h;
参考文献
Astellas Pharma Inc.
Patent: EP1647553 A1, 2006 ;
Location in patent: Page/Page column 23 ;
