7-羟基-3，4-二氢苯并吡喃合成路线 （共 13 条）
反应条件
ethanol; nickel
Hydrogenation;
参考文献
Naylor et al.
Journal of the Chemical Society, 1958 , p. 1190,1192
反应条件
palladium 10 on activated carbon; hydrogen in ethanol
4 h; Reflux;
参考文献
Wang, Shi-Hui; Wang, Yan; Zhu, Yu-Ying; Han, Jian; Zhou, Yi-Fan; Koirala, Diwa; Li, Da-Wei; Hu, Chun
Arkivoc, 2010 , vol. 2010, # 11 p. 204 - 214
反应条件
hydrogen; ethyl acetate; palladium on activated charcoal
P=760 Torr; 12 h;
参考文献
Cube, Rowena V.; Vernier, Jean-Michel; Hutchinson, John H.; Gardner, Michael F.; James, Joyce K.; Rowe, Blake A.; Schaffhauser, Herve; Daggett, Lorrie; Pinkerton, Anthony B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 9 p. 2389 - 2393
反应条件
palladium monocarbide in acetic acid; ethyl acetate
参考文献
Mitsui Petrochemical Industries, Ltd.
Patent: US4838924 A1, 1989 ;
反应条件
1: 87 percent / NaOH / H2O
2: 42 percent / K2CO3 / acetone / 40 °C
3: 100 percent / H2; ethyl acetate / Pd/C / 12 h / 760 Torr
View Scheme
参考文献
Cube, Rowena V.; Vernier, Jean-Michel; Hutchinson, John H.; Gardner, Michael F.; James, Joyce K.; Rowe, Blake A.; Schaffhauser, Herve; Daggett, Lorrie; Pinkerton, Anthony B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 9 p. 2389 - 2393
反应条件
1: 60 percent / triflic acid / 80 °C
2: 87 percent / NaOH / H2O
3: 42 percent / K2CO3 / acetone / 40 °C
4: 100 percent / H2; ethyl acetate / Pd/C / 12 h / 760 Torr
View Scheme
参考文献
Cube, Rowena V.; Vernier, Jean-Michel; Hutchinson, John H.; Gardner, Michael F.; James, Joyce K.; Rowe, Blake A.; Schaffhauser, Herve; Daggett, Lorrie; Pinkerton, Anthony B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 9 p. 2389 - 2393
反应条件
hydrogen bromide in acetic acid
T=100 - 110°C; Yield given;
参考文献
Shiratsuchi; Kawamura; Akashi; Fujii; Ishihama; Uchida
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 632 - 641
反应条件
1: H2 / 10 percent Pd-C / acetic acid / Ambient temperature
2: 47 percent (w/v) HBr / acetic acid / 100 - 110 °C
View Scheme
参考文献
Shiratsuchi; Kawamura; Akashi; Fujii; Ishihama; Uchida
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 632 - 641
反应条件
EtMgI; palladium on activated charcoal; acetic acid
T=170°C; Hydrogenation;
参考文献
Prillinger; Schmid
Monatshefte fuer Chemie, 1939 , vol. 72, p. 427,431
反应条件
1: perchloric acid / 0.5 h
2: 5 palladium on charcoal; hydrogen / ethanol / 48 h / 50 °C
View Scheme
参考文献
SHENYANG PHARMACEUTICAL UNIVERSITY; Hu, Chun; Wang, Shihui; Wang, Yan; Huang, Erfang; Liu, Xiaoping; Li, Dawei
Patent: US2013/96112 A1, 2013 ;
