hydrogenchloride 4 h; Heating;

1: 87 percent / 1N NaOH / CH2Cl2 / 5 h / Ambient temperature 2: 1.) sec-BuLi, N,N,N',N'-tetramethylethylenediamine / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h 3: 1.) MeI, 2.) 10percent aq. NaOH / 1.) THF, reflux, 4 h, 2.) THF, reflux, 7 h 4: 90 percent / 10percent aq. HCl / 4 h / Heating View Scheme

1: 1.) sec-BuLi, N,N,N',N'-tetramethylethylenediamine / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h 2: 1.) MeI, 2.) 10percent aq. NaOH / 1.) THF, reflux, 4 h, 2.) THF, reflux, 7 h 3: 90 percent / 10percent aq. HCl / 4 h / Heating View Scheme

1: 1.) MeI, 2.) 10percent aq. NaOH / 1.) THF, reflux, 4 h, 2.) THF, reflux, 7 h 2: 90 percent / 10percent aq. HCl / 4 h / Heating View Scheme