2-(3,4-二羟基苯基)乙醛合成路线 （共 17 条）
反应条件
sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine in dichloromethane; dimethyl sulfoxide
T=-15°C; Parikh-Doering Oxidation; 0.5 h; Inert atmosphere;
参考文献
Pesnot, Thomas; Gershater, Markus C.; Ward, John M.; Hailes, Helen C.
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 2997 - 3008
反应条件
Amberlite-H+ in tetrahydrofuran; water
4 h;
参考文献
Narayanan, Jayan; Hayakawa, Yoshio; Fan, Junfa; Kirk, Kenneth L.
Bioorganic Chemistry, 2003 , vol. 31, # 2 p. 191 - 197
参考文献
Fellman
Nature (London, United Kingdom), 1958 , vol. 182, p. 311
参考文献
Fellman
Nature (London, United Kingdom), 1958 , vol. 182, p. 311
反应条件
dimethylsulfide; boron trichloride in dichloromethane; 1,2-dichloro-ethane
24 h; Heating;
参考文献
Li, Shu Wen; Spaziano, Vincent T.; Burke, William J.
Bioorganic Chemistry, 1998 , vol. 26, # 1 p. 45 - 50
反应条件
1: conc. H2SO4 / Heating
2: pyridinium p-tosylate / CH2Cl2 / 1 h
3: 52 percent / DIBALH / toluene / 0.5 h / -78 °C
4: 50 percent / Amberlite-H+ / H2O; tetrahydrofuran / 4 h
View Scheme
参考文献
Narayanan, Jayan; Hayakawa, Yoshio; Fan, Junfa; Kirk, Kenneth L.
Bioorganic Chemistry, 2003 , vol. 31, # 2 p. 191 - 197
反应条件
1: pyridinium p-tosylate / CH2Cl2 / 1 h
2: 52 percent / DIBALH / toluene / 0.5 h / -78 °C
3: 50 percent / Amberlite-H+ / H2O; tetrahydrofuran / 4 h
View Scheme
参考文献
Narayanan, Jayan; Hayakawa, Yoshio; Fan, Junfa; Kirk, Kenneth L.
Bioorganic Chemistry, 2003 , vol. 31, # 2 p. 191 - 197
反应条件
1: 67 percent / NaOEt / ethanol / a) 0 deg C, 1 h, b) from 0 deg C to RT, overnight
2: 81 percent / aq. NaOH / Ambient temperature
3: 57 percent / AcOH / benzene / 4 h / Heating
4: 14 percent / BCl3/S(CH3)2 / 1,2-dichloro-ethane; CH2Cl2 / 24 h / Heating
View Scheme
参考文献
Li, Shu Wen; Spaziano, Vincent T.; Burke, William J.
Bioorganic Chemistry, 1998 , vol. 26, # 1 p. 45 - 50
反应条件
1: 81 percent / aq. NaOH / Ambient temperature
2: 57 percent / AcOH / benzene / 4 h / Heating
3: 14 percent / BCl3/S(CH3)2 / 1,2-dichloro-ethane; CH2Cl2 / 24 h / Heating
View Scheme
参考文献
Li, Shu Wen; Spaziano, Vincent T.; Burke, William J.
Bioorganic Chemistry, 1998 , vol. 26, # 1 p. 45 - 50
反应条件
1: 57 percent / AcOH / benzene / 4 h / Heating
2: 14 percent / BCl3/S(CH3)2 / 1,2-dichloro-ethane; CH2Cl2 / 24 h / Heating
View Scheme
参考文献
Li, Shu Wen; Spaziano, Vincent T.; Burke, William J.
Bioorganic Chemistry, 1998 , vol. 26, # 1 p. 45 - 50
