4-羟基-2-甲基苯甲酸乙酯合成路线 （共 14 条）
反应条件
1: 2 h / 135 °C 2: 34 percent / thionyl chloride / various solvent(s) / 1.5 h / 25 °C 3: 54 percent / NaI, K2CO3 / acetonitrile / 24 h / Heating View Scheme
参考文献
Diana, Guy D.; Oglesby, Richard C.; Akullian, Vahan; Carabateas, Phillip M.; Cutcliffe, David; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 383 - 388
参考文献
Sen, P. K.; Pal, Panchanan; Goswami, Shyamaprosad; Chattopadhyay, Gautam
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, p. 679 - 682
反应条件
hydrogen bromide; oxygen; copper(ll) bromide in 1,4-dioxane; water
T=20°C; 20 h; Sealed tube;
参考文献
Kikushima, Kotaro; Nishina, Yuta
RSC Advances, 2013 , vol. 3, # 43 p. 20150 - 20156
反应条件
sodium ethanolate in ethanol
T=25°C; 1 h;
参考文献
Smith, Amos B.; Kilenyi, Nicholas S.
Tetrahedron Letters, 1985 , vol. 26, # 37 p. 4419 - 4422
参考文献
Gomberg; Johnson
Journal of the American Chemical Society, 1917 , vol. 39, p. 1680
反应条件
iodine; sodium ethanolate in ethanol
Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Hegde, Shridhar G.; Kassim, Amude M.; Ingrum, April I.
Tetrahedron Letters, 1995 , vol. 36, # 46 p. 8395 - 8398
反应条件
iodine; sodium ethanolate in ethanol
Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Hegde, Shridhar G.; Kassim, Amude M.; Ingrum, April I.
Tetrahedron Letters, 1995 , vol. 36, # 46 p. 8395 - 8398
反应条件
1: 52 g / iodine/periodic acid / acetic acid; H2O; H2SO4 / 6 h
2: 1.) butyl-lithium / 1.) ether/hexane, -70 deg C, 45 min; 2.) ether/hexane
3: hydrobromic acid / aq. acetic acid / Heating
View Scheme
参考文献
Cornforth, Sir John; Kumar, Ashok; Stuart, Alan S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 859 - 866
反应条件
1: 1.) butyl-lithium / 1.) ether/hexane, -70 deg C, 45 min; 2.) ether/hexane
2: hydrobromic acid / aq. acetic acid / Heating
View Scheme
参考文献
Cornforth, Sir John; Kumar, Ashok; Stuart, Alan S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 859 - 866
反应条件
1: hydrobromic acid / aq. acetic acid / Heating
View Scheme
参考文献
Cornforth, Sir John; Kumar, Ashok; Stuart, Alan S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 859 - 866
