(R)-(-)-3-氯-1,2-丙二醇合成路线 （共 25 条）
反应条件
Candida-derived reductase; Reduced nicotinamide-adenine dinucleotide T=30°C; pH=6.5; 2 h; Aqueous phophate bufferEnzymatic reaction;
参考文献
EP1422213 A1, ;
Page 18 ;
反应条件
(S,S)-[1,2-cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]cobaltIII*OAc; water in tetrahydrofuran T=0 - 20°C;
参考文献
Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1307 - 1315
反应条件
potassium dihydrogenphosphate; D-glucose in water T=30°C; pH=5.5; 24 h; Aqueous phophate bufferMicrobiological reaction;
参考文献
EP1422213 A1, ;
Page 13 ;
反应条件
[(R,R)-N,N-bis-(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamino-Co(III)-acetate]; water in tetrahydrofuran T=4°C; 24 h;
参考文献
Furrow, Michael E.; Schaus, Scott E.; Jacobsen, Eric N.
Journal of Organic Chemistry, 1998 , vol. 63, # 20 p. 6776 - 6777
反应条件
water; dimeric chiral (salen)Co complex linked with Al T=20°C; 5 h; Product distribution; Further Variations:Catalysts;
参考文献
Berkessel, Albrecht; Ertuerk, Erkan
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 18 p. 2619 - 2625
反应条件
C72H102Co2F12N4O12P2; water T=0 - 20°C; 3 h; optical yield given as percent ee;
参考文献
Chemistry - A European Journal, , vol. 18, # 17 p. 5256 - 5260
反应条件
hydrogenchloride; sodium chloride; sodium nitrite in water T=10 - 20°C; Substitution; 24 h;
参考文献
Wang, Guijun; Hollingsworth, Rawle I.
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1036 - 1038
反应条件
potassium dioxotetrahydroxoosmate(VI); potassium carbonate; potassium hexacyanoferrate(III); 1,4-bis(dihydroquinidinyl)anthraquinone in water; tert-butyl alcohol T=0°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Angewandte Chemie, , vol. 108, # 4 p. 447 - 449
反应条件
(S,S)-[1,2-cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]cobaltIII*OAc; (salen)Co(III)-AlCl3; water in tetrahydrofuran T=19.84°C; 3 h; Kinetics; Reagent/catalystSolvent; optical yield given as percent eeenantioselective reaction;
参考文献
Jiang, Chengjun
Kinetics and Catalysis, 2011 , vol. 52, # 5 p. 691 - 696
反应条件
sodium hydroxide; PEP; adenosine 5'-triphosphoric acid; 2-hydroxyethanethiol; magnesium chloride in water T=27°C; 120 h; pH=7.5; Yield given. Yields of byproduct given;
参考文献
Journal of the American Chemical Society, , vol. 107, # 24 p. 7019 - 7027
