(R)-(-)-3-氯-1,2-丙二醇合成路线 (共 25 条)
反应条件
in tetrahydrofuran; water
反应条件
polistyrene-bound (R,R)-N-(3,5-di-t-butyl-6-hydroxy)benzylidene-N'-(3-t-butyl-2,5-dihydroxy)benzylidene-1,2-cyclohexanediamine; water in dichloromethane 3 h; Ambient temperature; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 121, # 17 p. 4147 - 4154
反应条件
epoxide hydrolase from Agrobacterium radiobacter AD1; halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; kinetic resolution; pH=7.5; 20 h; Further byproducts given;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
water T=20°C; 8 h; optical yield given as percent ee;
参考文献
Zheng, Xiaolai; Jones, Christopher W.; Weck, Marcus
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 2 p. 255 - 261
参考文献
Kawakami, Yuhsuke; Asai, Tamio; Umeyama, Kiyoshi; Yamashita, Yuya
Journal of Organic Chemistry, 1982 , vol. 47, # 18 p. 3581 - 3585
反应条件
sodium tetrahydroborate in ethanol
参考文献
Ellis, Martin K.; Golding, Bernard T.; Watson, William P.
Journal of the Chemical Society, Chemical Communications, 1984 , # 23 p. 1600 - 1602
反应条件
water; poly(Co(III)(OTs)-salen-norbornene) in chlorobenzene T=20°C; 0.5 h; Product distribution; Further Variations:Catalystsreaction times;
参考文献
Journal of Organic Chemistry, , vol. 71, # 5 p. 1825 - 1836
反应条件
sodium hydroxide; sodium azide; acid phosphatase; pyruvate kinase; Phosphoenolpyruvate; glycerol kinase from Streptomyces canus; potassium chloride; adenosine 5'-triphosphoric acid; 2-hydroxyethanethiol; magnesium chloride 1.) H2O, 25 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 63, # 12 p. 4039 - 4045
反应条件
porcine pancreatic lipase; sodium methylate 1) H2O (pH:7), r.t., 2) MeOH, r.t., 4h; Multistep reaction;
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 10 p. 2211 - 2218
反应条件
hydrogenchloride; sodium tetrahydroborate 2) MeOH, reflux, 3h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 4 p. 747 - 755