乙氧基-2-亚甲基三氟乙酰乙酸乙酯合成路线 （共 36 条）
反应条件
acetic anhydride T=120 - 140°C; Condensation; 7 h;
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
参考文献
Pryadeina; Burgart; Saloutin; Slepukhin; Kazheva; Shilov; D'yachenko; Chupakhin
Russian Journal of Organic Chemistry, 2007 , vol. 43, # 7 p. 945 - 955
反应条件
1: hydrazine hydrate / ethanol / 12 h / 20 °C / Inert atmosphere 2: hydrogenchloride; acetic acid / water / 6 h / Inert atmosphere; Reflux View Scheme
参考文献
Gerus, Igor I.; Mironetz, Roman X.; Kondratov, Ivan S.; Bezdudny, Andrei V.; Dmytriv, Yurii V.; Shishkin, Oleg V.; Starova, Viktoriia S.; Zaporozhets, Olga A.; Tolmachev, Andrey A.; Mykhailiuk, Pavel K.
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 47 - 56
反应条件
sodium ethanolate in ethanol Condensation; cyclization; 6 h; Heating;
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1: 45 percent / NaOEt / ethanol / Heating 2: POCl3 / 1 h / Heating 3: 1 N aq. NaOH / tetrahydrofuran View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1: 78 percent / triethylamine / ethanol / -15 deg C - RT, 1 h 2: 67 percent / KOH / ethanol / 2 h / Heating View Scheme
参考文献
Beck, James R.; Wright, Fred L.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 739 - 740
反应条件
1: 65 percent / triethylamine / ethanol / -15 deg C - RT, 1 h 2: 67 percent / KOH / ethanol / 2 h / Heating View Scheme
参考文献
Beck, James R.; Wright, Fred L.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 739 - 740
反应条件
1: hydrazine hydrate / methanol / 3 h / 80 °C 2: copper diacetate; pyridine / N,N-dimethyl-formamide / 24 h / 20 °C View Scheme
参考文献
Wu, Zhibing; Hu, Deyu; Kuang, Jiqing; Cai, Hua; Wu, Shixi; Xue, Wei
Molecules, 2012 , vol. 17, # 12 p. 14205 - 14218
反应条件
1: hydrazine hydrate / methanol / 3 h / 80 °C 2: copper diacetate; pyridine / N,N-dimethyl-formamide / 24 h / 20 °C 3: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 70 °C / pH 5 View Scheme
参考文献
Wu, Zhibing; Hu, Deyu; Kuang, Jiqing; Cai, Hua; Wu, Shixi; Xue, Wei
Molecules, 2012 , vol. 17, # 12 p. 14205 - 14218
反应条件
triethylamine in ethanol -15 deg C - RT, 1 h;
参考文献
Beck, James R.; Wright, Fred L.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 739 - 740
