乙氧基-2-亚甲基三氟乙酰乙酸乙酯合成路线 （共 36 条）
反应条件
1: 58 percent / NaOEt / ethanol / 6 h / Heating 2: 82 percent / aq. NaOH / tetrahydrofuran View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
sodium ethanolate in ethanol Condensation; cyclization; 24 h; Heating;
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
hydrazine hydrate in ethanol T=0 - 20°C; 4.5 h;
参考文献
Guillou, Sandrine; Bonhomme, Frederic J.; Ermolenko, Mikhail S.; Janin, Yves L.
Tetrahedron, 2011 , vol. 67, # 44 p. 8451 - 8457
反应条件
1: 45 percent / NaOEt / ethanol / Heating 2: POCl3 / 1 h / Heating View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1: methylhydrazine With hydrogenchloride in ethanol T=0°C; 0.5 h; 2: ethyl 2-ethoxymethylidene-3-oxo-3-trifluoromethylpropionate in ethanol T=0°C; 18 h; 3: With sodium carbonate in ethanol; water
参考文献
PFIZER JAPAN INC.; PFIZER INC.; RENOVIS, INC.
Patent: WO2008/59370 A2, 2008 ;
Location in patent: Page/Page column 52 ;
WO 2008/059370 A2
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 2 h;
参考文献
WO2004/14844 A2, ;
Page 282-283 ;
WO 2004/014844 A2
反应条件
1: 39 percent / NaOEt / ethanol / 24 h / Heating 2: 25 percent / aq. NaOH / ethanol / 1 h / 20 °C View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1: sodium ethanolate / ethanol / 16 h / 20 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Bach, Peter; Bostroem, Jonas; Brickmann, Kay; Van Giezen; Hovland, Ragnar; Petersson, Annika U.; Ray, Asim; Zetterberg, Fredrik
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2877 - 2881
反应条件
triethylamine in acetic acid T=175°C; P=105011 Torr; Sonication;
参考文献
Obermayer, David; Glasnov, Toma N.; Kappe, C. Oliver
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6657 - 6669
反应条件
triethylamine in acetonitrile T=60°C;
参考文献
US2009/209556 A1, ;
Page/Page column 17 ;
