9H-咔唑-3,6-二甲腈合成路线 （共 6 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide 2 h; Heating;
参考文献
Velasco, Dolores; Castellanos, Sonia; Lopez, Marc; Lopez-Calahorra, Francisco; Brillas, Enric; Julia, Luis
Journal of Organic Chemistry, 2007 , vol. 72, # 20 p. 7523 - 7532
反应条件
1: in N,N-dimethyl-formamide
T=150°C; 48 h; Inert atmosphere;
2: With hydrogenchloride; anhydrous iron chloride in water; N,N-dimethyl-formamide
2 h; Inert atmosphere;
参考文献
Wu, Shaofei; Liu, Yao; Yu, Guipeng; Guan, Jianguo; Pan, Chunyue; Du, Yong; Xiong, Xiang; Wang, Zhonggang
Macromolecules, 2014 , vol. 47, # 9 p. 2875 - 2882
反应条件
in N,N-dimethyl-formamide
70 h; Heating;
参考文献
Patrick; Boykin; Wilson; Tanious; Spychala; Bender; Hall; Dykstra; Ohemeng; Tidwell
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 10 p. 781 - 793
反应条件
1.1: bromine / chloroform / 13 h / 0 - 20 °C
2.1: N,N-dimethyl-formamide / 48 h / 150 °C / |Inert atmosphere
2.2: 2 h / |Inert atmosphere
View Scheme
参考文献
Wu, Shaofei; Liu, Yao; Yu, Guipeng; Guan, Jianguo; Pan, Chunyue; Du, Yong; Xiong, Xiang; Wang, Zhonggang
Macromolecules, 2014 , vol. 47, # 9 p. 2875 - 2882
参考文献
Preston et al.
Journal of the Chemical Society, 1942 , p. 500,503
反应条件
in N-methyl-acetamide
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4061655 A1, 1977 ;
