5-[3-(三氟甲基)苯基]-1,3,4-恶二唑-2-胺合成路线 （共 2 条）
反应条件
Oxonereg;; iodine; sodium hydroxide in water; isopropyl alcohol
T=0 - 20°C; 0.5 h;
参考文献
Shinde, Vikas N.; Ugarkar, Bheemarao G.; Ghorpade, Sandeep R.
Journal of Chemical Research, 2013 , vol. 37, # 1 p. 53 - 54
反应条件
1: tetrahydrofuran / 24 h / 0 - 20 °C / |Inert atmosphere
2: potassium iodide; sodium hydroxide; 1,3-dibromo-5,5-dimethyl-hydantoin / isopropyl alcohol; water; acetonitrile / 1 h / 0 - 4 °C
View Scheme
参考文献
Zender, Michael; Klein, Tobias; Henn, Claudia; Kirsch, Benjamin; Maurer, Christine K.; Kail, Dagmar; Ritter, Christiane; Dolezal, Olan; Steinbach, Anke; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6761 - 6774
