2-氨基-3-硝基苯甲酸甲酯合成路线 （共 20 条）
反应条件
thionyl chloride in methanol T=0°C; 23 h; Heating / reflux;
参考文献
NIPPON CHEMIPHAR CO., LTD.
Patent: EP1452528 A1, 2004 ;
Location in patent: Page 21-22 ;
反应条件
1: 2-Amino-3-nitro-benzoic acid With lithium hydroxide hydrate T=20°C; 1 h; 2: dimethyl sulfate in tetrahydrofuran 24 h; Reflux;
参考文献
GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; ENGELS, Michael; GERMANN, Tieno; DE VRY, Jean; JOSTOCK, Ruth; HEES, Sabine
Patent: WO2010/142402 A1, 2010 ;
Location in patent: Page/Page column 109-110 ;
反应条件
potassium carbonate in methanol T=60°C; 1 h;
参考文献
Safonov, Igor G.; Heerding, Dirk A.; Keenan, Richard M.; Price, Alan T.; Erickson-Miller, Connie L.; Hopson, Christopher B.; Levin, Jenna L.; Lord, Kenneth A.; Tapley, Peter M.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1212 - 1216
反应条件
hydrogenchloride in water; tert-butyl alcohol Heating / reflux;
参考文献
WO2006/15134 A1, ;
Page/Page column 14 ;
反应条件
hydrogenchloride in methanol
反应条件
in methanol; diethyl ether T=20°C;
参考文献
WO2007/51062 A2, ;
Page/Page column 132 ;
WO 2007/051062 A2
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 119 - 124
反应条件
1: acetic anhydride; acetic acid; nitric acid / 2.5 h / 5 - 15 °C 2: sodium methoxide / methanol / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 17 p. 6106 - 6119
反应条件
1: acetic acid; nitric acid / acetic anhydride / 0.33 h / 18 - 20 °C 2: sulfuric acid / 0.5 h / 0 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 3 p. 490 - 493
反应条件
1: 93 percent / Br2; aq. KOH / 3 h / 60 °C 2: 60 percent / HCl(g) / 6 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 22 p. 4084 - 4097
