2-氨基-3-硝基苯甲酸甲酯合成路线 （共 20 条）
反应条件
1: sulfuric acid / 2.5 h / 90 °C / |Inert atmosphere 2: sodium hydroxide; dihydrogen peroxide / water / 0 - 20 °C / |Inert atmosphere 3: hydrogenchloride / water / 12 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 17 p. 8217 - 8231
反应条件
1: hydroxylamine hydrochloride; sodium sulfate; hydrogenchloride / water / 65 °C / |Inert atmosphere 2: sulfuric acid / 2.5 h / 90 °C / |Inert atmosphere 3: sodium hydroxide; dihydrogen peroxide / water / 0 - 20 °C / |Inert atmosphere 4: hydrogenchloride / water / 12 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 17 p. 8217 - 8231
反应条件
1: sodium hydroxide; dihydrogen peroxide / water / 0 - 20 °C / |Inert atmosphere 2: hydrogenchloride / water / 12 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 17 p. 8217 - 8231
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 8 h / |Inert atmosphere 2: water / 0.75 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Wang, Jingjing; Zuo, Sujing; Chen, Weiqiang; Zhang, Xinrui; Tan, Kaixin; Tian, Yun; Wang, Jianhui
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8217 - 8231
反应条件
1: With hydrogen bromide in 1,4-dioxane; water T=20°C; 2: With sodium nitrite in 1,4-dioxane; water T=0°C; 0.75 h; 3: With hydrogen bromide; copper(I) bromide in 1,4-dioxane; water T=0°C; Sandmeyer reaction; 1 h; Reflux;
参考文献
Wang, Ping; Zheng, Guo-Jun; Wang, Ya-Ping; Wang, Xiang-Jing; Li, Yan; Xiang, Wen-Sheng
Tetrahedron, 2010 , vol. 66, # 29 p. 5402 - 5406
反应条件
1: 64 percent / Et3N / tetrahydrofuran / 12 h / 20 °C 2: 75 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
hydrogen; 20 Pd(OH)2 on carbon in ethanol T=20°C; P=3040.2 Torr; 48 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.; DISCH, Jeremy, S.; NG, Pui, Yee; BLUM, Charles, A.; PERNI, Robert, B.
Patent: WO2010/3048 A1, 2010 ;
Location in patent: Page/Page column 117 ;
WO 2010/003048 A1
反应条件
palladium in ethanol
参考文献
Ferraris, Dana V.; Li, Jia-He; Kalish, Vincent J.; Zhang, Jie
Patent: US2003/22883 A1, 2003 ;
反应条件
1: H2 / Pd(OH)2/C / methanol / 760 Torr
2: BH3*pyridine / methanol / 20 °C
View Scheme
参考文献
Beaulieu, Pierre L.; Boes, Michael; Bousquet, Yves; Fazal, Gulrez; Gauthier, Jean; Gillard, James; Goulet, Sylvie; LaPlante, Steven; Poupart, Marc-Andre; Lefebvre, Sylvain; McKercher, Ginette; Pellerin, Charles; Austel, Volkhard; Kukolj, George
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 119 - 124
反应条件
bromine in acetic acid
T=20°C; 0.5 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2003/105846 A1, 2003 ;
Location in patent: Page 48 ;
WO 03/105846 A1
