2-((5-(4-(叔丁氧基羰基)哌嗪-1-基)吡啶-2-基)氨基)-8-环戊基-5-甲基-7-氧代-7,8-二氢吡啶并[2,3-d]嘧啶-6-羧酸乙酯合成路线 （共 6 条）
反应条件
in toluene
T=100°C; 10 h;
参考文献
Barvian, Mark; Booth, Richard John; Ouin III, John; Thomas Repine, Joseph; Sheehan, Derek J.; Toogood, Peter Laurence; Vanderwel, Scott Norman; Zhou, Hairong
Patent: US2003/149001 A1, 2003 ;
US 20030149001 A1
反应条件
1: 190.93 g / aq. NaHCO3 / tetrahydrofuran / 3 h
2: 83 percent / H2 / Raney Nickel / methanol / 5 h / 2585.74 Torr
3: 29 percent / toluene / 10 h / 100 °C
View Scheme
参考文献
Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406
反应条件
1: 83 percent / H2 / Raney Nickel / methanol / 5 h / 2585.74 Torr
2: 29 percent / toluene / 10 h / 100 °C
View Scheme
参考文献
Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406
反应条件
1: tetra-n-butylammonium iodide; K2CO3 / dimethylsulfoxide / 80 - 100 °C
2: 190.93 g / aq. NaHCO3 / tetrahydrofuran / 3 h
3: 83 percent / H2 / Raney Nickel / methanol / 5 h / 2585.74 Torr
4: 29 percent / toluene / 10 h / 100 °C
View Scheme
参考文献
Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406
反应条件
1: 36 percent / Pd(OAc)2; bis(diphenylphosphinic)propane; iPr2NEt / 16 h / 100 °C / 31028.9 Torr
2: 76 percent / 2-benzenesulfonyl-3-phenyloxaziridine / CH2Cl2 / 18 h / 20 °C
3: 29 percent / toluene / 10 h / 100 °C
View Scheme
参考文献
Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406
反应条件
1: 76 percent / 2-benzenesulfonyl-3-phenyloxaziridine / CH2Cl2 / 18 h / 20 °C
2: 29 percent / toluene / 10 h / 100 °C
View Scheme
参考文献
Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406
