5-氯-4-硝基-2,1,3-苯噁二唑合成路线 （共 14 条）
参考文献
Ghosh,P.B.; Whitehouse,M.W.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 305 - 311
参考文献
Ghosh,P.B.; Whitehouse,M.W.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 305 - 311
参考文献
Ghosh,P.B.; Whitehouse,M.W.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 305 - 311
参考文献
Ghosh,P.B.; Whitehouse,M.W.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 305 - 311
参考文献
Ghosh,P.B.; Whitehouse,M.W.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 305 - 311
反应条件
sulfuric acid; nitric acid
T=0°C;
参考文献
Crampton, Michael R.; Lunn, Rachel E.A.; Lucas, David
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3438 - 3443
反应条件
1: KOH, NaOCl / aq. ethanol
2: (i) NH2OH*HCl, EtOH, H2O, (ii) KOH
3: HNO3, H2SO4
View Scheme
参考文献
Ghosh,P.B.; Whitehouse,M.W.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 305 - 311
反应条件
1: 40 percent / hydroxylamine; aq. KOH / ethanol / 1 h / 20 °C
2: 20 percent / nitric acid; H2SO4 / 0 °C
View Scheme
参考文献
Crampton, Michael R.; Lunn, Rachel E.A.; Lucas, David
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3438 - 3443
反应条件
1: P(OEt)3 / ethanol
2: H2SO4, HNO3
View Scheme
参考文献
Boulton,A.J. et al.
Journal of the Chemical Society, 1965 , p. 5958 - 5964
反应条件
1: acetic acid
2: P(OEt)3 / ethanol
3: H2SO4, HNO3
View Scheme
参考文献
Boulton,A.J. et al.
Journal of the Chemical Society, 1965 , p. 5958 - 5964
